Département de Microbiologie et Infectiologie, Centre Hospitalier de l'Université de Montréal, Quebec, Canada.
Clin Infect Dis. 2014 Mar;58(6):840-7. doi: 10.1093/cid/cit714. Epub 2013 Oct 30.
Liver disease, specifically cirrhosis, is a leading cause of morbidity and mortality in human immunodeficiency virus (HIV)-infected patients. The diagnosis of early cirrhosis in HIV/hepatitis C virus (HCV)-coinfected patients may be challenging. The development of noninvasive methods for fibrosis assessment empowers the infectious disease specialist to diagnose advanced fibrosis or cirrhosis. Early diagnosis is essential to enroll patients in screening programs for esophageal varices and hepatocellular carcinoma. Cirrhosis may also modify decisions about treatment of both HIV and HCV, including vaccination, medications chosen, and referral for liver transplant.
肝脏疾病，特别是肝硬化，是导致人类免疫缺陷病毒（HIV）感染患者发病率和死亡率的主要原因。在 HIV/丙型肝炎病毒（HCV）合并感染患者中早期肝硬化的诊断可能具有挑战性。纤维化评估的非侵入性方法的发展使传染病专家能够诊断出晚期纤维化或肝硬化。早期诊断对于将患者纳入食管静脉曲张和肝细胞癌的筛查计划至关重要。肝硬化也可能改变 HIV 和 HCV 治疗的决策，包括疫苗接种、选择的药物和肝移植的转诊。
