患有几种神经疾病的患者脑脊液中的游离-GABA 水平其在诊断伴有炎症和组织坏死的疾病中的潜在用途。

Free-GABA levels in the cerebrospinal fluid of patients suffering from several neurological diseases Its potential use for the diagnosis of diseases which course with inflammation and tissular necrosis.

机构信息

Department of Neurosciences, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Apartado 70-253, 04510, México, D.F..

出版信息

Amino Acids. 1995 Sep;9(3):207-16. doi: 10.1007/BF00805952.

DOI:10.1007/BF00805952

PMID:24178837

Abstract

Free GABA levels were measured in the cerebrospinal fluid (CSF) of 74 neurological patients suffering from cerebral cysticercosis (n = 9), Parkinson's disease (n = 5), multiple sclerosis (n = 6), epilepsy (n = 24), meningeal tuberculosis (n = 6), viral encephalitis (n = 3), cerebrovascular disease (n = 8) and several kinds of dystonia (n = 5). A statistical significant four-fold elevation in free GABA levels was found in patients with cerebral cysticercosis. A non statistical significant two-fold increase in free GABA levels was also encountered in the CSF of patients affected by cerebrovascular disease and viral encephalitis. No changes in CSF free GABA levels were found in patients suffering from any of the other disorders. It is suggested that free GABA levels may be elevated in the CSF of patients suffering from neurological diseases which course with inflammation and tissular necrosis such as cerebral cysticercosis. Much work is needed however to establishd whether CSF free GABA levels can be used as a diagnostic tool in at least some type of these patients.

摘要

我们测量了 74 名患有脑囊虫病（9 例）、帕金森病（5 例）、多发性硬化症（6 例）、癫痫（24 例）、脑膜结核（6 例）、病毒性脑炎（3 例）、脑血管疾病（8 例）和多种类型的肌张力障碍（5 例）等神经系统疾病患者的脑脊液（CSF）中的游离 GABA 水平。我们发现患有脑囊虫病的患者的游离 GABA 水平显著升高了 4 倍。患有脑血管病和病毒性脑炎的患者的 CSF 中游离 GABA 水平也升高了两倍，但没有统计学意义。而患有其他疾病的患者的 CSF 中游离 GABA 水平没有变化。这表明游离 GABA 水平可能在患有炎症和组织坏死等神经疾病的患者的 CSF 中升高，例如脑囊虫病。然而，还需要做大量工作来确定 CSF 游离 GABA 水平是否可以作为这些患者中至少某些类型的诊断工具。