脑囊尾蚴病患者血清及脑脊液中的抗囊尾蚴抗体
Anticysticercous antibodies in serum and cerebrospinal fluid in patients with cerebral cysticercosis.
作者信息
Corona T, Pascoe D, González-Barranco D, Abad P, Landa L, Estañol B
出版信息
J Neurol Neurosurg Psychiatry. 1986 Sep;49(9):1044-9. doi: 10.1136/jnnp.49.9.1044.
Abstract
Fifty-one cases of cerebral cysticercosis proved by surgery or CT scanning were studied prospectively with the ELISA test in order to detect anticysticercous antibodies in blood and CSF. The ELISA test was also performed for detection of antibodies in 20 control patients who had CSF withdrawn during a myelogram and in 119 serum samples of asymptomatic subjects. We found an overall sensitivity of the ELISA test in the blood of 87% with a specificity of 90%. In the CSF we found a sensitivity of 87% with a specificity of 100%. However, when we compared patients with cerebral cysticercosis of a benign type with patients with cerebral cysticercosis of a malignant type we found a serum sensitivity of 75% for the benign group as compared to 93% of the malignant group. The CSF sensitivity was 80% in the benign group and 93% in the malignant group. This difference was statistically significant.
摘要
为了检测血液和脑脊液中抗囊尾蚴抗体，我们对51例经手术或CT扫描证实的脑囊尾蚴病患者进行了前瞻性酶联免疫吸附测定（ELISA）检测。同时，对20例在脊髓造影时抽取脑脊液的对照患者以及119例无症状受试者的血清样本也进行了ELISA检测，以检测抗体。我们发现ELISA检测在血液中的总体敏感性为87%，特异性为90%。在脑脊液中，敏感性为87%，特异性为100%。然而，当我们将良性脑囊尾蚴病患者与恶性脑囊尾蚴病患者进行比较时，发现良性组血清敏感性为75%，而恶性组为93%。良性组脑脊液敏感性为80%，恶性组为93%。这种差异具有统计学意义。
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