School of Life Sciences, Tsinghua University, Beijing, 100084, China.
J Mater Sci Mater Med. 2014 Feb;25(2):561-71. doi: 10.1007/s10856-013-5073-4. Epub 2013 Nov 1.
Two types of fibers were prepared by using bio-based materials: a mono-filament made from poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) and a multi-filament made from poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and polylactic acid (PLA) blend. The two fibers were evaluated for mechanical properties, biocompatibility and degradability for the potential application as medical sutures. The PHBHHx fiber showed remarkable biocompatibility by H.E. Stainning, with very little impact to the surrounding tissues. The degradation of the fiber was observed by SEM after implantation for 36 weeks, and the major degradation product was detected after 96 weeks. Consistently, the PHBHHx fiber maintained more than half of the mechanical properties after 96 weeks. The other fiber was prepared by twisting PHBV/PLA blend strands to a bunch, and showed high biocompatibility and relatively high degradability. The bunched structure loosed after 36 weeks of implantation. These low-cost and easily prepared fibers have great potential in medical applications, since they could avoid the formation of fibrous capsule, reduce the size of scar, and degrade into non-toxic and even beneficial products.
一种是由聚（3-羟基丁酸酯-共-3-羟基己酸酯）（PHBHHx）制成的单丝，另一种是由聚（3-羟基丁酸酯-共-3-羟基戊酸酯）（PHBV）和聚乳酸（PLA）共混物制成的多丝。这两种纤维的机械性能、生物相容性和可降解性进行了评估，以作为医用缝线的潜在应用。HE 染色表明，PHBHHx 纤维具有显著的生物相容性，对周围组织的影响很小。植入 36 周后通过 SEM 观察到纤维的降解，96 周后检测到主要的降解产物。同样，PHBHHx 纤维在 96 周后仍保持超过一半的机械性能。另一种纤维是通过将 PHBV/PLA 共混物的股线捻成一束制备的，表现出良好的生物相容性和较高的可降解性。植入 36 周后，束状结构开始松解。这些低成本、易于制备的纤维在医学应用中具有很大的潜力，因为它们可以避免纤维囊的形成，减少疤痕的大小，并降解为无毒甚至有益的产物。
