Kanno A, Ohori H, Nagatsuka Y, Sekino H, Tateda A, Goto Y, Ishida N
J Med Virol. 1986 Jan;18(1):1-10. doi: 10.1002/jmv.1890180102.
The patients and staff members of a haemodialysis unit were examined for their serological responses to SO-antigen, which was isolated from the urine of epidemic type non-A, non-B hepatitis patients at Tohoku University Hospital. To understand how SO-antigen or SO-antigen-related aetiology can be incriminated for the hepatitis found in the haemodialysis unit, the prevalence of SO-antigen/anti-SO system and hepatitis A and B virus-related antibodies was compared in the sera of patients and staff members. Although the SO-antigen was rarely detected in the serum, anti-SO antibody was frequently detected in the sera of patients and staff. A significantly higher prevalence was found in the serum of patients (15%, 54 out of 361) than staff members (7.1%, 13 out of 184) and volunteer blood donors (1%, 3 out of 305). The same prevalence percentages of HBV-related antibodies (either positive for anti-HBs or anti-HBc) and anti-HAV were observed among the patients, staff, and volunteer blood donors, irrespective of whether the sera were anti-SO positive or negative. Among the staff, anti-SO antibody was more frequently found in those with a history of acute hepatitis (16.7%, 3 out of 18) than in those without (6%, 10 out of 166). These prevalence ratios conformed with those of HBV-related antibodies, but the same prevalence ratios of antibody to HAV were observed between the staff with and without a history of acute hepatitis. These results indicate that the SO-antigen/anti-SO system or entity related to this immune system is distinct from HBV or HAV, and this immune system was found widely in the haemodialysis unit where type B and non-A, non-B hepatitis were also found frequently.
对一家血液透析单位的患者和工作人员进行了检测，以了解他们对SO抗原的血清学反应。SO抗原是从东北大学医院的非甲非乙型流行性肝炎患者尿液中分离出来的。为了弄清楚在该血液透析单位发现的肝炎中，SO抗原或与SO抗原相关的病因是如何被牵连的，比较了患者和工作人员血清中SO抗原/抗SO系统以及甲型和乙型肝炎病毒相关抗体的流行情况。尽管在血清中很少检测到SO抗原，但在患者和工作人员的血清中经常检测到抗SO抗体。患者血清中的流行率（15%，361人中有54人）显著高于工作人员（7.1%，184人中有13人）和志愿献血者（1%，305人中有3人）。在患者、工作人员和志愿献血者中，无论血清抗SO是阳性还是阴性，乙肝病毒相关抗体（抗HBs或抗HBc阳性）和抗HAV的流行率百分比相同。在工作人员中，有急性肝炎病史的人（16.7%，18人中有3人）比没有急性肝炎病史的人（6%，166人中有10人）更频繁地检测到抗SO抗体。这些流行率与乙肝病毒相关抗体的流行率相符，但有和没有急性肝炎病史的工作人员中抗HAV的流行率相同。这些结果表明，SO抗原/抗SO系统或与该免疫系统相关的实体与乙肝病毒或甲肝病毒不同，并且在经常发现乙型和非甲非乙型肝炎的血液透析单位中广泛存在这种免疫系统。
