Chen Shanying, Chen Youming, Liu Xinyu, Li Mi, Wu Bide, Li Yongqiang, Liang Yan, Shao Xiaofei, Holthöfer Harry, Zou Hequn
Department of Nephrology, The Third Affiliated Hospital of Southern Medical University, 183# Zhongshan Dadao, Tianhe District, Guangzhou, 510000, People's Republic of China.
Endocrine. 2014 Aug;46(3):496-504. doi: 10.1007/s12020-013-0079-8. Epub 2013 Nov 5.
We performed this study to investigate the prevalences of insulin resistance and metabolic syndrome (MetS) in a Chinese population with normal weight. We also examined whether fat mass is associated with insulin resistance and MetS in normal-weight individuals. Data were drawn from a cross-sectional study in China. Subjects with diabetes were excluded. The prevalences of insulin resistance and MetS were calculated. Multivariate logistic regression analysis was performed repeated separately for body mass index (BMI) and waist circumference (WC) in both men and women. We also used the combination of BMI and WC to predict insulin resistance and MetS. 8.55 % of normal-weight men and 12.62 % of normal-weight women had insulin resistance. 7.41 % of normal-weight men and 10.24 % of normal-weight women had MetS. WC was associated with incident insulin resistance and MetS independent of BMI in both men and women. BMI was independently associated with incident MetS in women. Normal-weight individuals with insulin resistance and/or MetS are not rare in the Chinese population. Fat mass is associated with insulin resistance and MetS in normal-weight subjects. The current findings support using both BMI and WC in clinical practice.
我们开展这项研究旨在调查正常体重的中国人群中胰岛素抵抗和代谢综合征（MetS）的患病率。我们还研究了正常体重个体的脂肪量是否与胰岛素抵抗和MetS相关。数据取自中国的一项横断面研究。排除患有糖尿病的受试者。计算胰岛素抵抗和MetS的患病率。分别对男性和女性的体重指数（BMI）和腰围（WC）进行重复的多变量逻辑回归分析。我们还使用BMI和WC的组合来预测胰岛素抵抗和MetS。8.55%的正常体重男性和12.62%的正常体重女性存在胰岛素抵抗。7.41%的正常体重男性和10.24%的正常体重女性患有MetS。在男性和女性中，WC均与新发胰岛素抵抗和MetS相关，且独立于BMI。BMI在女性中与新发MetS独立相关。在中国人群中，存在胰岛素抵抗和/或MetS的正常体重个体并不罕见。正常体重受试者的脂肪量与胰岛素抵抗和MetS相关。目前的研究结果支持在临床实践中同时使用BMI和WC。
