Singh Preeti, Ali S Wazed, Kale Ravindra D
Fibers & Textile Processing Technology, Institute of Chemical Technology, Mumbai, India.
Department of Textile and Fibre Engineering, Indian Institute of Technology Delhi, Hauz Khas, New Delhi 110016, India.
ACS Omega. 2023 Feb 21;8(9):8159-8171. doi: 10.1021/acsomega.2c06343. eCollection 2023 Mar 7.
Controlling bioaerosols has become increasingly critical in affecting human health. Natural product treatment in the nano form is a potential method since it has lower toxicity than inorganic nanomaterials like silver nanoparticles. This research is important for the creation of a bioaerosol control system that is effective. Nanoparticles (NPs) are gradually being employed to use bacteria as a nonantibiotic substitute for treating bacterial infections. The present study looks at nanoparticles' antimicrobial properties, their method of action, their impact on drug-opposing bacteria, and the hazards connected with their operation as antimicrobial agents. The aspects that influence nanoparticle conduct in clinical settings, as well as their distinctive features and mode of action as antibacterial assistants, are thoroughly examined. Nanoparticles' action on bacterial cells is presently accepted by way of the introduction of oxidative stress induction, metal-ion release, and nonoxidative methods. Because many concurrent mechanisms of action against germs would necessitate multiple simultaneous gene modifications in the same bacterial cell for antibacterial protection to evolve, bacterial cells developing resistance to NPs is difficult. This review discusses the antimicrobial function of NPs against microbes and presents a comprehensive discussion of the bioaerosols: their origin, hazards, and their prevention. This state of the art method is dependent upon the use of personal protective gear against these bioaerosols. The benefit of the utmost significant categories of metal nanoparticles as antibacterial agents is given important consideration. The novelty of this review depends upon the antimicrobial properties of (a) silver (Ag), (b) zinc oxide (ZnO), and (c) copper oxide (CuO) nanoparticles. The value-added features of these nanoparticles are discussed, as well as their physicochemical characterization and pharmacokinetics, including the toxicological danger they pose to people. Lastly, the effective role of nanomaterials and their future in human wellness is discussed.
控制生物气溶胶对人类健康的影响日益关键。纳米形式的天然产物处理是一种潜在方法,因为它比银纳米颗粒等无机纳米材料毒性更低。这项研究对于创建有效的生物气溶胶控制系统至关重要。纳米颗粒(NPs)正逐渐被用于将细菌作为治疗细菌感染的非抗生素替代品。本研究着眼于纳米颗粒的抗菌特性、其作用方式、对耐药细菌的影响以及与它们作为抗菌剂使用相关的危害。深入研究了影响纳米颗粒在临床环境中行为的因素,以及它们作为抗菌辅助剂的独特特征和作用方式。目前,纳米颗粒对细菌细胞的作用被认为是通过引入氧化应激诱导、金属离子释放和非氧化方法来实现的。由于针对细菌的许多并发作用机制需要在同一细菌细胞中同时进行多个基因修饰才能使抗菌保护进化,所以细菌细胞对纳米颗粒产生抗性很困难。本综述讨论了纳米颗粒对微生物的抗菌功能,并对生物气溶胶进行了全面讨论:它们的来源、危害及其预防。这种先进方法依赖于使用针对这些生物气溶胶的个人防护装备。重点考虑了最重要类别的金属纳米颗粒作为抗菌剂的益处。本综述的新颖之处在于(a)银(Ag)、(b)氧化锌(ZnO)和(c)氧化铜(CuO)纳米颗粒的抗菌特性。讨论了这些纳米颗粒的增值特性,以及它们的物理化学表征和药代动力学,包括它们对人类构成的毒理学危险。最后,讨论了纳米材料在人类健康方面的有效作用及其未来发展。