艾滋病患者颈淋巴结和腭扁桃体中 CD1a(+)、CD83(+) 和因子 XIIIa(+)树突状细胞减少。

Decreased CD1a(+) , CD83(+) and factor XIIIa(+) dendritic cells in cervical lymph nodes and palatine tonsils of AIDS patients.

机构信息

Department of Pathology, Federal University of Santa Catarina, Florianópolis, Brazil.

出版信息

Histopathology. 2014 Jan;64(2):234-41. doi: 10.1111/his.12256. Epub 2013 Nov 6.

DOI:10.1111/his.12256

PMID:24192235

Abstract

AIMS

The purpose of this study was to quantify and compare the density of dendritic cells (DCs) in cervical lymph nodes (LNs) and palatine tonsils (PTs) of AIDS and non-AIDS patients.

METHODS AND RESULTS

Factor XIIIa, CD1a and CD83 antibodies were used to identify migratory DCs by immunohistochemistry in LNs and PTs of 32 AIDS patients and 21 HIV-negative control patients. Quantification was performed by the positive pixel count analytical method. AIDS patients presented a lower density of factor XIIIa(+) cells (P < 0.001), CD1a(+) cells (P < 0.05) and CD83(+) cells (P < 0.001) in cervical LNs and PTs compared to the non-AIDS control group.

CONCLUSION

Overall depletion of DCs in lymphoid tissues of AIDS patients may be predictive of the immune system's loss of disease control.

摘要

目的

本研究旨在定量和比较艾滋病（AIDS）和非艾滋病（非 AIDS）患者颈淋巴结（LNs）和腭扁桃体（PTs）中树突状细胞（DCs）的密度。

方法和结果

通过免疫组织化学，使用因子 XIIIa、CD1a 和 CD83 抗体来识别 LNs 和 PTs 中的迁移 DCs。通过阳性像素计数分析方法进行定量。与非 AIDS 对照组相比，AIDS 患者颈 LNs 和 PTs 中的因子 XIIIa(+)细胞（P < 0.001）、CD1a(+)细胞（P < 0.05）和 CD83(+)细胞（P < 0.001）密度较低。