Stemboroski Lauren, Samuel Joshua, Alkaddour Ahmad, Agresti Nicholas, Gupta Ena, Palacio Carlos, Munoz Juan Carlos, Deutch Amie, Yap John Erikson L, Vega Kenneth J
Gastroenterology, University of Florida - Jacksonville College of Medicine (COM), Jacksonville, USA.
Internal Medicine, University of Florida - Jacksonville College of Medicine (COM), Jacksonville, USA.
Cureus. 2021 Jul 5;13(7):e16200. doi: 10.7759/cureus.16200. eCollection 2021 Jul.
Background and aim Adenomatous polyps are precursor lesions for colorectal cancer (CRC). Serrated adenomas/polyps are considered a risk factor for the development of proximal and interval CRC. African-Americans are at higher risk for right-sided CRC. Minimal data evaluating serrated adenoma characteristics by race/ethnicity on initial screening colonoscopy (SC) exist. The aim of this investigation was to compare the characteristics of serrated adenomas found in non-Hispanic whites (nHw) and African-Americans (AA) undergoing initial SC. Methods The University of Florida-Jacksonville endoscopy database was searched for all SC performed between January 2000 and December 2014. Inclusion criteria were nHw or AA race/ethnicity and histologically proven serrated adenoma found at SC. Data were collected for all included age at SC, sex, number, location, and size of serrated adenomas found. Results A total of 8693 individuals (nHw - 4199 and AA - 4494) underwent SC between January 2000 and December 2014. Serrated adenomas were found in 479 individuals (nHw, n=294; AA, n=185), and AA were significantly less likely than nHw to have serrated adenomas on SC (AA 4.1% vs nHw 7%; p< 0.0001). No difference was observed in mean age, location, or size between nHw and AA with serrated adenomas. Conclusions Serrated adenomas are more frequent in nHw compared to AA at initial SC. No difference was seen in size or location of serrated adenomas, as well as patient age, between AA and nHw. A study of genetic factors predisposing to serrated adenoma formation and the impact of socioeconomic disparities should be performed across ethnic groups to understand this difference.
腺瘤性息肉是结直肠癌（CRC）的前驱病变。锯齿状腺瘤/息肉被认为是近端和间歇性CRC发生的危险因素。非裔美国人患右侧CRC的风险更高。关于在初次筛查结肠镜检查（SC）时按种族/民族评估锯齿状腺瘤特征的数据极少。本研究的目的是比较接受初次SC的非西班牙裔白人（nHw）和非裔美国人（AA）中发现的锯齿状腺瘤的特征。方法：检索佛罗里达大学杰克逊维尔分校的内镜数据库，查找2000年1月至2014年12月期间进行的所有SC。纳入标准为nHw或AA种族/民族，且在SC时经组织学证实为锯齿状腺瘤。收集所有纳入患者的SC年龄、性别、发现的锯齿状腺瘤数量、位置和大小等数据。结果：2000年1月至2014年12月期间，共有8693人（nHw - 4199人，AA - 4494人）接受了SC。479人发现有锯齿状腺瘤（nHw，n = 294；AA，n = 185），AA在SC时发现有锯齿状腺瘤的可能性显著低于nHw（AA为4.1%，nHw为7%；p < 0.0001）。有锯齿状腺瘤的nHw和AA在平均年龄、位置或大小方面未观察到差异。结论：在初次SC时，nHw中锯齿状腺瘤比AA更常见。AA和nHw在锯齿状腺瘤的大小、位置以及患者年龄方面均未发现差异。应跨种族进行研究，以了解导致锯齿状腺瘤形成的遗传因素以及社会经济差异的影响，从而解释这种差异。
