抗原诱导人白细胞嗜酸性粒细胞趋化因子（ECF）释放。
Antigen-induced eosinophil chemotactic factor (ECF) release by human leukocytes.
机构信息
Clinical Immunology Division, The Johns Hopkins University School of Medicine at The Good Samaritan Hospital, 5601 Loch Raven Boulevard, Baltimore, Maryland.
出版信息
Inflammation. 1976 Mar;1(2):201-15. doi: 10.1007/BF00917530.
A complement-independent eosinophil chemotactic factor (ECF) is described which is released from peripheral leukocytes of allergic and normal human volunteers after antigen stimulation and after exposure to anti-IgE. Dose response and time-release curves for ECF and histamine run closely parallel in this system. Histamine by itself is shown to have no effect on chemotaxis at the concentrations present in antigen-induced release, but is inhibitory at very high concentrations. Evidence suggests that the ECF released from human leukocytes is derived from basophils and is similar, or identical, to the ECF released from mast cells.
一种补体非依赖的嗜酸性粒细胞趋化因子（ECF）被描述出来，它可以从过敏和正常的人类志愿者的外周白细胞中释放出来，在抗原刺激和暴露于抗 IgE 后。在这个系统中，ECF 和组胺的剂量反应和时间释放曲线非常相似。组胺本身在抗原诱导释放中存在的浓度下对趋化作用没有影响，但在非常高的浓度下具有抑制作用。有证据表明，从人白细胞中释放的 ECF 来自于嗜碱性粒细胞，并且与从肥大细胞中释放的 ECF 相似或相同。
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