Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA 15232, USA.
Dev Biol. 2011 Jul 15;355(2):175-82. doi: 10.1016/j.ydbio.2011.02.033. Epub 2011 Mar 31.
The FaceBase Consortium consists of ten interlinked research and technology projects whose goal is to generate craniofacial research data and technology for use by the research community through a central data management and integrated bioinformatics hub. Funded by the National Institute of Dental and Craniofacial Research (NIDCR) and currently focused on studying the development of the middle region of the face, the Consortium will produce comprehensive datasets of global gene expression patterns, regulatory elements and sequencing; will generate anatomical and molecular atlases; will provide human normative facial data and other phenotypes; conduct follow up studies of a completed genome-wide association study; generate independent data on the genetics of craniofacial development, build repositories of animal models and of human samples and data for community access and analysis; and will develop software tools and animal models for analyzing and functionally testing and integrating these data. The FaceBase website (http://www.facebase.org) will serve as a web home for these efforts, providing interactive tools for exploring these datasets, together with discussion forums and other services to support and foster collaboration within the craniofacial research community.
脸数据库联盟由十个相互关联的研究和技术项目组成，其目标是通过中央数据管理和综合生物信息学中心，为研究界生成颅面研究数据和技术。该联盟由美国国立牙科和颅面研究所（NIDCR）资助，目前专注于研究面部中部的发育，将生成全球基因表达模式、调控元件和测序的综合数据集；生成解剖学和分子图谱；提供人类正常面部数据和其他表型；对已完成的全基因组关联研究进行后续研究；生成颅面发育遗传学的独立数据，构建动物模型和人类样本库，并为社区提供访问和分析的途径；并将开发用于分析、功能测试和整合这些数据的软件工具和动物模型。脸数据库网站（http://www.facebase.org）将作为这些工作的网络主页，提供用于探索这些数据集的交互工具，以及讨论论坛和其他服务，以支持和促进颅面研究界的合作。
