Department of Cell Biology, School of Basic Medical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China, Department of Biomedical Informatics, School of Basic Medical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China and MOE Key Lab of Cardiovascular Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China.
Nucleic Acids Res. 2014 Jan;42(Database issue):D1070-4. doi: 10.1093/nar/gkt1023. Epub 2013 Nov 4.
The Human microRNA Disease Database (HMDD; available via the Web site at http://cmbi.bjmu.edu.cn/hmdd and http://202.38.126.151/hmdd/tools/hmdd2.html) is a collection of experimentally supported human microRNA (miRNA) and disease associations. Here, we describe the HMDD v2.0 update that presented several novel options for users to facilitate exploration of the data in the database. In the updated database, miRNA-disease association data were annotated in more details. For example, miRNA-disease association data from genetics, epigenetics, circulating miRNAs and miRNA-target interactions were integrated into the database. In addition, HMDD v2.0 presented more data that were generated based on concepts derived from the miRNA-disease association data, including disease spectrum width of miRNAs and miRNA spectrum width of human diseases. Moreover, we provided users a link to download all the data in the HMDD v2.0 and a link to submit novel data into the database. Meanwhile, we also maintained the old version of HMDD. By keeping data sets up-to-date, HMDD should continue to serve as a valuable resource for investigating the roles of miRNAs in human disease.
人类 microRNA 疾病数据库（HMDD；可通过网站 http://cmbi.bjmu.edu.cn/hmdd 和 http://202.38.126.151/hmdd/tools/hmdd2.html 访问）是一个包含经过实验验证的人类 microRNA（miRNA）和疾病关联的集合。在这里，我们描述了 HMDD v2.0 的更新，为用户提供了几个新的选项，以方便在数据库中探索数据。在更新后的数据库中，miRNA-疾病关联数据被更详细地注释。例如，遗传学、表观遗传学、循环 miRNAs 和 miRNA 靶相互作用的 miRNA-疾病关联数据被整合到数据库中。此外，HMDD v2.0 还提供了更多基于 miRNA-疾病关联数据衍生的概念生成的数据，包括 miRNA 疾病谱宽度和人类疾病的 miRNA 谱宽度。此外，我们为用户提供了一个链接，可以下载 HMDD v2.0 中的所有数据，以及一个链接，可以将新数据提交到数据库中。同时，我们也保留了 HMDD 的旧版本。通过保持数据集的最新，HMDD 应该继续成为研究 miRNA 在人类疾病中的作用的有价值资源。
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