Tanaka M, Takahashi T, Shinkawa O, Furuhashi N
Nihon Sanka Fujinka Gakkai Zasshi. 1986 Jan;38(1):59-63.
In this study, we measured cord serum thyroxine (T4), triiodothyronine (T3), reverse T3 (rT3), thyroxine binding globulin (TBG) and thyroid-stimulating hormone (TSH) in 37 fetuses (29-42 gestational weeks). The mean cord serum TBG was 18.2 +/- 3.2 mg/dl (mean +/- S.E., n = 37) and there was no correlation between cord serum TBG levels and gestational weeks. The cord serum T3 levels increased with advancing gestational weeks. On the other hand, cord serum rT3 levels decreased with advancing gestational weeks. There was a significant positive correlation between the TBG and T4 levels after 32 gestational weeks (n = 34, r = 0.545, p less than 0.001), and between the TBG and T3 levels (n = 36, r = 0.65, p less than 0.001). There was a significant positive correlation between the TBG and T3 levels after 37 gestational weeks (n = 24, r = 0.43, p less than 0.05). The cord serum TSH levels had a significant difference (p less than 0.05) between preterm fetus (n = 11, 12.8 +/- 2.2 mU/ml, mean +/- S.E.) and term fetus (n = 25, 8.2 +/- 0.8 mU/ml). The T4/TSH ratio in the preterm fetus (0.65 +/- 0.01) was significantly smaller (p less than 0.001) than that of term fetus (1.60 +/- 0.16). These results suggest that thyroid hormones are closely related with TBG in fetus and the sensitivity of the thyroid gland to TSH may increase with advancing gestational weeks.
在本研究中，我们测量了37例胎儿（孕29 - 42周）脐带血清中的甲状腺素（T4）、三碘甲状腺原氨酸（T3）、反三碘甲状腺原氨酸（rT3）、甲状腺素结合球蛋白（TBG）和促甲状腺激素（TSH）。脐带血清TBG的平均值为18.2±3.2mg/dl（平均值±标准误，n = 37），脐带血清TBG水平与孕周之间无相关性。脐带血清T3水平随孕周增加而升高。另一方面，脐带血清rT3水平随孕周增加而降低。孕32周后（n = 34，r = 0.545，p＜0.001），TBG与T4水平之间存在显著正相关，TBG与T3水平之间也存在显著正相关（n = 36，r = 0.65，p＜0.001）。孕37周后（n = 24，r = 0.43，p＜0.05），TBG与T3水平之间存在显著正相关。早产胎儿（n = 11，12.8±2.2mU/ml，平均值±标准误）与足月胎儿（n = 25，8.2±0.8mU/ml）的脐带血清TSH水平存在显著差异（p＜0.05）。早产胎儿的T4/TSH比值（0.65±0.01）显著低于足月胎儿（1.60±0.16）（p＜0.0
