Xu Shaoyong, Gao Bin, Xing Ying, Ming Jie, Bao Junxiang, Zhang Qiang, Wan Yi, Ji Qiuhe
Department of Endocrinology, the First Affiliated Hospital of Fourth Military Medical University, Xi'an, China.
PLoS One. 2013 Oct 23;8(10):e78270. doi: 10.1371/journal.pone.0078270. eCollection 2013.
Not all the people with metabolic syndrome (MS) have abdominal obesity (AO). The study aimed to investigate gender differences in the prevalence and development of MS in Chinese population with abdominal obesity, which has rarely been reported.
Data were obtained from the 2007-08 China National Diabetes and Metabolic Disorders Study, and participants were divided into two samples for analysis. Sample 1 consisted of 19,046 people with abdominal obesity, while sample 2 included 2,124 people meeting pre-specified requirements. Survival analysis was used to analyze the development of MS.
The age-standardized prevalence of MS in Chinese population with AO was 49.5%. The prevalence in males (73.7%) was significantly higher than that in females (36.9%). Males had significantly higher proportions of combinations of three or four MS components than females (36.4% vs. 30.2% and 18.4% vs. 5%, respectively). MS developed quick at first and became slow down later. Half of the participants with AO developed to MS after 3.9 years (95% CI: 3.7-4.1) from the initial metabolic abnormal component, whereas 75% developed to MS after 7.7 years (95% CI: 7.5-7.9).
Compared with females, Chinese males with AO should receive more attention because of their higher prevalence of MS and its components, more complex and risky combinations of abnormal components, and faster development of MS.
并非所有代谢综合征(MS)患者都有腹型肥胖(AO)。本研究旨在调查中国腹型肥胖人群中MS患病率及发展情况的性别差异,此前鲜有相关报道。
数据来自2007 - 2008年中国国家糖尿病和代谢紊乱研究,参与者被分为两个样本进行分析。样本1由19046名腹型肥胖者组成,样本2包括2124名符合预先设定要求的人。采用生存分析来分析MS的发展情况。
中国腹型肥胖人群中MS的年龄标准化患病率为49.5%。男性患病率(73.7%)显著高于女性(36.9%)。男性出现三或四项MS组分组合的比例显著高于女性(分别为36.4%对30.2%和18.4%对5%)。MS起初发展迅速,随后变慢。半数腹型肥胖参与者从最初的代谢异常组分起3.9年(95%可信区间:3.7 - 4.1)后发展为MS,而75%在7.7年(95%可信区间:7.5 - 7.9)后发展为MS。
与女性相比,中国腹型肥胖男性应受到更多关注,因为他们MS及其组分的患病率更高,异常组分的组合更复杂且风险更大,MS发展更快。