Department of Maternal and Child Health, School of Public Health, Sun Yat-sen University.
Institute of Child and Adolescent Health, School of Public Health, Peking University.
J Atheroscler Thromb. 2020 Jun 1;27(6):534-544. doi: 10.5551/jat.50591. Epub 2019 Dec 11.
Metabolic syndrome (MetS) has become a worldwide epidemic; however, few studies have described its status in Chinese children. This study aimed to estimate MetS status and its associations with geography, economic development, birth weight, and parental education of Chinese children and adolescents.
Data were derived from 15,045 participants aged 7-18 years across seven Chinese provinces. Physical measurement and blood tests were conducted to assess the five classical MetS components described by the International Diabetes Federation, including abdominal obesity (the essential component), high blood pressure, low high-density cholesterol (HDL-C), high triglyceride, and elevated fasting glucose (FG). Logistic regression was adopted to explore possible associations between MetS and other factors.
Overall, MetS prevalence was 2.3%, higher in males (2.8% vs. 1.7% in females), northern regions (3.1%), more developed regions (2.9%), and older participants (aged 16-18 years) (P＜0.05 for all). Among the five MetS components, abdominal obesity and low HDL-C level were most prevalent (21.8% and 14.4%), and 35.9% of the participants had at least one component. In logistic regression, MetS itself did not correlate with birth weight or parental education. High birth weight was positively correlated with abdominal obesity (odds ratio, 1.48) butnegatively associated with elevated FG (odds ratio, 0.49). Concusions: MetS itself was not common in Chinese children and adolescents, whereas its certain components were far more prevalent. Children from North China, more-developed areas, and at an older age were more likely to develop MetS. Strategies designed to prevent pediatric MetS in China should focus on prevalent components as well as its geographic and economic development predilections.
代谢综合征（MetS）已成为全球性流行疾病，但鲜有研究描述中国儿童的代谢综合征现状。本研究旨在评估中国儿童和青少年代谢综合征的患病情况及其与地理位置、经济发展、出生体重和父母教育的关系。
数据来自中国 7 个省份的 15045 名 7-18 岁儿童和青少年。通过体格测量和血液检测评估国际糖尿病联盟定义的 5 个经典代谢综合征组分，包括腹型肥胖（必要组分）、高血压、低高密度脂蛋白胆固醇（HDL-C）、高三酰甘油和空腹血糖升高。采用 logistic 回归分析探讨代谢综合征与其他因素之间的可能关联。
总体而言，代谢综合征的患病率为 2.3%，男性（2.8%）高于女性（1.7%），北方地区（3.1%）高于南方地区，经济发达地区（2.9%）高于经济欠发达地区，年龄较大的参与者（16-18 岁）患病率更高（所有 P 值均＜0.05）。在 5 个代谢综合征组分中，腹型肥胖和低 HDL-C 水平最为常见（分别为 21.8%和 14.4%），35.9%的参与者至少存在 1 个组分。logistic 回归分析显示，代谢综合征本身与出生体重或父母教育无相关性。高出生体重与腹型肥胖呈正相关（比值比 1.48），与空腹血糖升高呈负相关（比值比 0.49）。结论：代谢综合征本身在我国儿童和青少年中并不常见，但某些组分的患病率较高。来自中国北方、经济发达地区和年龄较大的儿童发生代谢综合征的风险更高。在中国预防儿童代谢综合征的策略应关注常见组分以及其地理位置和经济发展倾向。
