Chia W, Savakis C, Karp R, Pelham H, Ashburner M
J Mol Biol. 1985 Dec 20;186(4):679-88. doi: 10.1016/0022-2836(85)90388-2.
AdhnLA248 is an X-ray-induced mutation of the alcohol dehydrogenase gene of Drosophila melanogaster that lacks detectable ADH protein but is transcribed. The transcript of this mutant allele is longer than that of the wild type. This is because the mutation is a duplication of parts of the second and third exons of Adh and of the intron that normally separates them. The primary transcript of the mutant allele is processed by the removal of both of the identical copies of intron 3. This mutation presumably originated, in the haploid sperm, as two staggered single-stranded breaks that gave rise to the duplication as a consequence of replication after fertilization.
AdhnLA248是果蝇酒精脱氢酶基因的一种X射线诱导突变体，它缺乏可检测到的ADH蛋白，但能转录。该突变等位基因的转录本比野生型的长。这是因为该突变是Adh基因第二和第三外显子以及通常分隔它们的内含子部分的重复。突变等位基因的初级转录本通过去除内含子3的两个相同拷贝进行加工。这种突变可能起源于单倍体精子中的两个交错单链断裂，受精后复制导致了这种重复。
