Pyo Jong-Ok, Yoo Seung-Min, Jung Yong-Keun
Bio-MAX Institute, Seoul National University School of Biological Sciences, Seoul, Korea.
Diabetes Metab J. 2013 Oct;37(5):333-9. doi: 10.4093/dmj.2013.37.5.333.
Numerous studies have established a link between autophagy and aging; however, the relationship has not been clearly defined. Aging is a very complex process caused by the accumulation of various factors due to the gradual failure of cellular maintenance. Recent studies have shown that autophagy reduces the stress responses induced by starvation, reactive oxygen species, and the accumulation of intracellular proteins and organelles through cytoprotection, clearance of damaged mitochondria, and lysosomal degradation. Here, we summarize our current understanding of the relationship between autophagy and the aging process.
众多研究已证实自噬与衰老之间存在联系；然而，这种关系尚未明确界定。衰老是一个非常复杂的过程，由于细胞维持功能逐渐失效，各种因素不断积累所致。最近的研究表明，自噬通过细胞保护、清除受损线粒体以及溶酶体降解，减少了由饥饿、活性氧以及细胞内蛋白质和细胞器积累所诱导的应激反应。在此，我们总结了目前对自噬与衰老过程之间关系的理解。
