Mao Zhi-Min, Huang Yan-Ru, Wan Yi-Gang, Chen Hao-Li, Shi Xi-Miao, Meng Xian-Jie, Yao Jian
Zhongguo Zhong Yao Za Zhi. 2014 Oct;39(19):3707-12.
In the development of diabetic nephropathy (DN), reactive oxygen specie (ROS) over much in vivo leads to oxidative stress(OS)-related renal injuries, which are characterized by the structural and functional changes in glomerular and renal tubular cells in morphology. The regulative approaches of OS involve the several signaling pathways, in which, both p38 mitogen-activated protein kinase (MAPK) signaling pathway and adenosine monophosphate-activated protein kinase (AMPK) signaling pathway play the important roles as the target of anti-oxidants. The interventional actions of Chinese herbal compound prescriptions and the extracts of single Chinese herbal medicine (CHM) on OS in the kidney in DN include regulating the balance between ROS and antioxidants, reducing the production of AGEs, inhibiting the expression of growth factors and intervening the activity of signaling pathways.
在糖尿病肾病（DN）的发展过程中，体内活性氧（ROS）过多会导致与氧化应激（OS）相关的肾损伤，其特征是肾小球和肾小管细胞在形态学上发生结构和功能变化。OS的调节途径涉及多个信号通路，其中p38丝裂原活化蛋白激酶（MAPK）信号通路和腺苷单磷酸活化蛋白激酶（AMPK）信号通路作为抗氧化剂的作用靶点发挥着重要作用。中药复方制剂和单味中药提取物对DN肾脏OS的干预作用包括调节ROS与抗氧化剂之间的平衡、减少晚期糖基化终末产物（AGEs）的产生、抑制生长因子的表达以及干预信号通路的活性。
