Cardiff School of Health Sciences, Cardiff Metropolitan University, Western Avenue, Llandaff, CF5 2YB, UK.
Future Microbiol. 2013 Nov;8(11):1419-29. doi: 10.2217/fmb.13.105.
Resistance to antibiotics continues to rise and few new therapies are on the horizon. Honey has good antibacterial activity against numerous microorganisms of many different genera and no honey-resistant phenotypes have yet emerged. The mechanisms of antimicrobial activity are just beginning to be understood; however, it is apparent that these are diverse and often specific for certain groups or even species of bacteria. Manuka honey has been most thoroughly characterized and is commercially available as a topical medical treatment for wound infections. Furthermore, since most data are available for this honey, there is a considerable focus on it in this review. It is becoming evident that honeys are more than just bactericidal, as they impact on biofilm formation, quorum sensing and the expression of virulence factors. With this in mind, honey represents an attractive antimicrobial treatment that might have the potential to be used alongside current therapies as a prophylactic or to treat wound infection with multidrug-resistant bacteria in future.
抗生素耐药性持续上升，新的治疗方法寥寥无几。蜂蜜对许多不同属的多种微生物具有良好的抗菌活性，而且尚未出现对蜂蜜有耐药性的表型。抗菌活性的机制才刚刚开始被理解；然而，很明显，这些机制是多种多样的，而且通常针对某些细菌属甚至种。麦卢卡蜂蜜的特征最为明显，并且已作为一种局部治疗伤口感染的医疗用蜂蜜在商业上使用。此外，由于大多数数据都可用于这种蜂蜜，因此在本综述中对其进行了大量的关注。越来越明显的是，蜂蜜不仅具有杀菌作用，还能影响生物膜的形成、群体感应以及毒力因子的表达。有鉴于此，蜂蜜作为一种有吸引力的抗菌治疗方法，有可能在未来与当前的治疗方法一起作为预防措施或用于治疗多药耐药菌引起的伤口感染。
