Nakagawa Shinichi, Kageyama Yuji
RNA Biology Laboratory, RIKEN, 2-1 Hirosawa, Saitama 351-0198, Japan.
Laboratory of Molecular Biology, Research Center for Environmental Genomics, Kobe University, 1-1 Rokkodai, Nada, Kobe 657-8501, Japan; Graduate School of Science, Kobe University, 1-1 Rokkodai, Nada, Kobe 657-8501, Japan.
Biochim Biophys Acta. 2014 Mar;1839(3):215-22. doi: 10.1016/j.bbagrm.2013.10.009. Epub 2013 Nov 5.
Systematic transcriptome analysis has revealed that a vast majority of the mammalian genome is transcribed into RNA, thus establishing the concept of "pervasive transcription." More than half of these RNAs do not encode proteins, and they are collectively called noncoding RNAs. Although the physiological relevance of the transcription of these noncoding RNAs has remained unclear, it was recently proposed that one of the major roles of long noncoding RNAs (lncRNAs) in the nucleus is the regulation of gene expression at the transcriptional level via histone or DNA modification. In this review, we will summarize the advancement of our understanding of the molecular mechanisms of lncRNAs. This article is part of a Special Issue entitled: Chromatin and epigenetic regulation of animal development.
系统转录组分析表明，绝大多数哺乳动物基因组都转录为RNA，从而确立了“广泛转录”的概念。这些RNA中一半以上不编码蛋白质，它们被统称为非编码RNA。尽管这些非编码RNA转录的生理相关性仍不清楚，但最近有人提出，长链非编码RNA（lncRNA）在细胞核中的主要作用之一是通过组蛋白或DNA修饰在转录水平上调控基因表达。在这篇综述中，我们将总结我们对lncRNA分子机制理解的进展。本文是名为：动物发育的染色质和表观遗传调控的特刊的一部分。
