Wu Xiaoben, Xia Pengcheng, Yang Lei, Lu Chao, Lu Zhiming
Department of Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Department of Medical Engineering, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Noncoding RNA Res. 2024 Mar 16;9(3):659-666. doi: 10.1016/j.ncrna.2024.03.008. eCollection 2024 Sep.
Alzheimer's disease (AD) is the most frequent type of dementia, presenting a substantial danger to the health and well-being of the aged population. It has arisen as a significant public health problem with considerable socioeconomic repercussions. Unfortunately, no effective treatments or diagnostic tools are available for Alzheimer's disease. Despite substantial studies on the pathophysiology of Alzheimer's, the molecular pathways underpinning its development remain poorly understood. Long non-coding RNAs (lncRNAs) vary in size from 200 nucleotides to over 100 kilobytes and have been found to play critical roles in various vital biological processes that play critical in developing Alzheimer's disease. This review intends to examine the functions of long non-coding RNAs in diagnosing and treating Alzheimer's disease and their participation in immunological responses associated with AD.
阿尔茨海默病（AD）是最常见的痴呆类型，对老年人群的健康和福祉构成重大威胁。它已成为一个具有重大社会经济影响的重要公共卫生问题。不幸的是，目前尚无针对阿尔茨海默病的有效治疗方法或诊断工具。尽管对阿尔茨海默病的病理生理学进行了大量研究，但其发病的分子途径仍知之甚少。长链非编码RNA（lncRNAs）的大小从200个核苷酸到超过100千字节不等，已发现它们在阿尔茨海默病发展过程中起关键作用的各种重要生物学过程中发挥关键作用。本综述旨在探讨长链非编码RNA在阿尔茨海默病诊断和治疗中的作用及其参与与AD相关的免疫反应的情况。
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