Hiragami-Hamada Kyoko, Fischle Wolfgang
Laboratory of Chromatin Biochemistry, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany.
Laboratory of Chromatin Biochemistry, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany.
Biochim Biophys Acta. 2014 Aug;1839(8):737-42. doi: 10.1016/j.bbagrm.2014.03.015. Epub 2014 Apr 2.
The regulatory role of histone modifications with respect to the structure and function of chromatin is well known. Proteins and protein complexes establishing, erasing and binding these marks have been extensively studied. RNAs have only recently entered the picture of epigenetic regulation with the discovery of a vast number of long non-coding RNAs. Fast growing evidence suggests that such RNAs influence all aspects of histone modification biology. Here, we focus exclusively on the emerging functional interplay between RNAs and proteins that bind histone modifications. We discuss recent findings of reciprocally positive and negative regulations as well as summarize the current insights into the molecular mechanism directing these interactions. This article is part of a Special Issue entitled: Molecular mechanisms of histone modification function.
组蛋白修饰对染色质结构和功能的调控作用已广为人知。对建立、消除和结合这些标记的蛋白质及蛋白质复合物已进行了广泛研究。直到最近，随着大量长链非编码RNA的发现，RNA才进入表观遗传调控领域。越来越多的证据表明，此类RNA影响组蛋白修饰生物学的各个方面。在此，我们专门聚焦于RNA与结合组蛋白修饰的蛋白质之间新出现的功能相互作用。我们讨论了相互正向和负向调控的最新发现，并总结了目前对指导这些相互作用的分子机制的见解。本文是名为“组蛋白修饰功能的分子机制”的特刊的一部分。
