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[作为酒渣鼻特殊形式的莫尔比昂病:发病机制综述及新治疗选择]

[Morbihan disease as a special form of rosacea: review of pathogenesis and new therapeutic options].

作者信息

Balakirski G, Baron J M, Megahed M

机构信息

Klinik für Dermatologie und Allergologie, Universitätsklinikum der RWTH Aachen, Pauwelsstr. 30, 52074, Aachen, Deutschland,

出版信息

Hautarzt. 2013 Dec;64(12):884-6. doi: 10.1007/s00105-013-2642-x.

DOI:10.1007/s00105-013-2642-x
PMID:24201653
Abstract

Morbihan disease is classified as a special form of rosacea, which presents with persistent facial erythema and solid edema because of marked involvement of the lymphatic vessels. The cheeks, nose and forehead are particularly affected. Currently, the treatment options of this cosmetically very disturbing disease are limited. However, every attempt should be made to provide treatment because of the great emotional suffering of the patients. We review some new currently available therapeutic options for Morbihan disease. In our patient, we were able to achieve a significant improvement with systemic isotretinoin 30 mg/day over a period of 12 months.

摘要

莫尔比昂病被归类为酒渣鼻的一种特殊形式,由于淋巴管的明显受累,表现为持续性面部红斑和实性水肿。脸颊、鼻子和前额尤其受到影响。目前,这种对容貌影响极大的疾病的治疗选择有限。然而,鉴于患者巨大的精神痛苦,应尽一切努力提供治疗。我们回顾了一些目前可用于治疗莫尔比昂病的新疗法。在我们的患者中,每天口服30毫克异维A酸,持续12个月,病情得到了显著改善。

相似文献

1
[Morbihan disease as a special form of rosacea: review of pathogenesis and new therapeutic options].[作为酒渣鼻特殊形式的莫尔比昂病:发病机制综述及新治疗选择]
Hautarzt. 2013 Dec;64(12):884-6. doi: 10.1007/s00105-013-2642-x.
2
[Lupoid rosacea as a special form of rosacea: review of pathogenesis and therapeutic options].[类狼疮样酒渣鼻作为酒渣鼻的一种特殊形式:发病机制与治疗选择综述]
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Morbihan disease: a therapeutic challenge.莫尔比昂病:一项治疗挑战。
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Morbihan Disease - An Old and Rare Entity Still Difficult to Treat.莫比汉病——一种古老而罕见的疾病,仍然难以治疗。
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Rosacea treatment with intermediate-dose isotretinoin: follow-up with erythema and sebum measurements.中剂量异维 A 酸治疗酒渣鼻:红斑和皮脂测量的随访。
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Case report: A therapeutic attempt to treat Morbihan disease with Baricitinib.病例报告:用巴瑞替尼治疗莫尔比昂病的治疗尝试。
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Diagnosis and Treatment of Morbihan's Disease: A Practical Approach based on Review of the Literature.莫尔比昂病的诊断与治疗:基于文献综述的实用方法
J Clin Aesthet Dermatol. 2023 Oct;16(10):22-30.
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Effective Treatment of Morbihan's Disease with Long-term Isotretinoin: A Report of Three Cases.长期使用异维A酸有效治疗莫尔比昂病:三例报告

本文引用的文献

1
Successful Long-term Use of Oral Isotretinoin for the Management of Morbihan Disease: A Case Series Report and Review of the Literature.口服异维A酸长期成功治疗莫尔比昂病:病例系列报告及文献综述
Arch Dermatol. 2012 Dec;148(12):1395-8. doi: 10.1001/archdermatol.2012.3109.
2
[Chronic eyelid oedema and rosacea (Morbus Morbihan): diagnostic and therapeutic challenges].[慢性眼睑水肿与酒渣鼻(莫尔比昂病):诊断与治疗挑战]
Klin Monbl Augenheilkd. 2011 Jan;228(1):19-24. doi: 10.1055/s-0029-1245960. Epub 2011 Jan 19.
3
TLR2 expression is increased in rosacea and stimulates enhanced serine protease production by keratinocytes.
J Clin Aesthet Dermatol. 2019 Jan;12(1):32-34. Epub 2019 Jan 1.
4
Efficacy of long-term intralesional triamcinolone in Morbihan's disease and its possible association with mast cell infiltration.长期病灶内曲安奈德治疗 Morbihan 病的疗效及其与肥大细胞浸润的可能相关性。
Dermatol Ther. 2018 Jul;31(4):e12609. doi: 10.1111/dth.12609. Epub 2018 Apr 23.
TLR2 的表达在酒渣鼻中增加,并刺激角质形成细胞产生增强的丝氨酸蛋白酶。
J Invest Dermatol. 2011 Mar;131(3):688-97. doi: 10.1038/jid.2010.351. Epub 2010 Nov 25.
4
[Morbus Morbihan : A rare cause of edematous swelling of the eyelids].[莫尔比昂病:眼睑水肿肿胀的罕见病因]
Ophthalmologe. 2010 Jun;107(6):553-7. doi: 10.1007/s00347-009-2083-1.
5
The molecular pathology of rosacea.酒渣鼻的分子病理学
J Dermatol Sci. 2009 Aug;55(2):77-81. doi: 10.1016/j.jdermsci.2009.04.007. Epub 2009 May 29.
6
[Persistent erythema and edema of the face associated with rosacea and lymph vessel dysplasia].[与酒渣鼻和淋巴管发育异常相关的面部持续性红斑和水肿]
Hautarzt. 1998 Dec;49(12):932-5. doi: 10.1007/s001050050851.
7
[Morbihan disease--chronic persistent erythema and edema of the face].
Hautarzt. 1995 Nov;46(11):796-8. doi: 10.1007/s001050050341.