Uri A K, Wetmore R F, Iozzo R V
Cancer. 1986 May 1;57(9):1803-9. doi: 10.1002/1097-0142(19860501)57:9<1803::aid-cncr2820570916>3.0.co;2-e.
An unusual epithelial neoplasm arising in the tongue of a 17 month-old-boy was studied by light and electron microscopy. By routine light microscopic examination, the tumor cells exhibited clear cytoplasm. Histochemical studies revealed the presence of large amounts of periodic acid-Schiff (PAS)-positive, diastase-labile material in the cytoplasm. Ultrastructurally, this material was identified as electron dense particles (20-35 nm diameter) of beta-glycogen. The epithelial nature of the tumor cells was suggested by the presence of intercellular junctions, segments of basal lamina, and well-developed Golgi complexes. Furthermore, the cells were often clustered and formed abnormal lumina with small microvillus projections. Several histologic features, such as lack of capsule, infiltration of muscle and invasion of blood vessel, indicated that this neoplasm was malignant. However, there was no recurrence or distant metastases more than 2.5 years after surgical excision, suggesting a low-grade malignancy. The glycogen-rich clear cell variant of adenocarcinoma is histogenetically derived from minor salivary glands like most of the glandular neoplasms in the oral cavity. Investigation of the literature on adult and childhood minor salivary gland neoplasms revealed that the glycogen-rich, clear-cell variant of adenocarcinoma has not previously been reported in the tongue.
对一名17个月大男孩舌部出现的一种罕见上皮性肿瘤进行了光镜和电镜研究。通过常规光镜检查，肿瘤细胞显示出透明的细胞质。组织化学研究显示细胞质中存在大量过碘酸希夫（PAS）阳性、淀粉酶敏感物质。超微结构上，这种物质被鉴定为β-糖原的电子致密颗粒（直径20 - 35纳米）。细胞间连接、基底膜片段和发育良好的高尔基体的存在提示了肿瘤细胞的上皮性质。此外，细胞常聚集成簇并形成带有小微绒毛突起的异常管腔。一些组织学特征，如无包膜、肌肉浸润和血管侵犯，表明该肿瘤为恶性。然而，手术切除后超过2.5年没有复发或远处转移，提示为低级别恶性肿瘤。富含糖原的透明细胞腺癌变体在组织发生上与大多数口腔腺性肿瘤一样，起源于小唾液腺。对成人和儿童小唾液腺肿瘤文献的研究表明，此前舌部尚未报道过富含糖原的透明细胞腺癌变体。
