Werther C A, Cloud H, Ohtake M, Tamura T
Drug Nutr Interact. 1986;4(3):269-74.
Anticonvulsant therapy is known to be associated with elevated plasma copper and ceruloplasmin levels. To investigate the effect of long-term phenytoin and/or phenobarbital administration, plasma copper, zinc, and ceruloplasmin levels were measured in two groups of patients with developmental disorders who were either living at home (study 1) or institutionalized (study 2). Plasma copper and zinc levels were measured using an atomic absorption spectrophotometric method, and ceruloplasmin levels were determined using a method measuring oxidase activity (study 1) and an immunodiffusion plate method (study 2). In both studies, the mean plasma copper and ceruloplasmin levels of the anticonvulsant groups were significantly higher than those of control groups, while the mean plasma zinc levels for the anticonvulsant and control groups were similar. Possible change in the tissue zinc/copper ratio among the patients receiving long-term anticonvulsants is discussed.
已知抗惊厥治疗与血浆铜和铜蓝蛋白水平升高有关。为了研究长期服用苯妥英和/或苯巴比妥的影响，对两组发育障碍患者的血浆铜、锌和铜蓝蛋白水平进行了测量，这两组患者分别是居家生活的（研究1）和住在福利院的（研究2）。血浆铜和锌水平采用原子吸收分光光度法测量，铜蓝蛋白水平采用测量氧化酶活性的方法（研究1）和免疫扩散平板法（研究2）测定。在两项研究中，抗惊厥组的平均血浆铜和铜蓝蛋白水平均显著高于对照组，而抗惊厥组和对照组的平均血浆锌水平相似。文中讨论了长期接受抗惊厥药物治疗的患者组织锌/铜比值可能发生的变化。
