黑腹果蝇中玫瑰色基因座的分子图谱
Molecular mapping of the rosy locus in Drosophila melanogaster.
作者信息
Coté B, Bender W, Curtis D, Chovnick A
出版信息
Genetics. 1986 Apr;112(4):769-83. doi: 10.1093/genetics/112.4.769.
Abstract
The DNA from the chromosomal region of the Drosophila rosy locus has been examined in 83 rosy mutant strains. Several spontaneous and radiation-induced alleles were associated with insertions and deletions, respectively. The lesions are clustered in a 4-kb region. Some of the alleles identified on the DNA map have been located on the genetic map by fine-structure recombination experiments. The genetic and molecular maps are collinear, and the alignment identifies the DNA location of the rosy control region. A rosy RNA of 4.5 kb has been identified; its 5' end lies in or near the control region.
摘要
在83个果蝇朱红基因座的突变菌株中，对其染色体区域的DNA进行了检测。几个自发突变和辐射诱导的等位基因分别与插入和缺失有关。这些损伤集中在一个4kb的区域。通过精细结构重组实验，已将DNA图谱上鉴定出的一些等位基因定位到遗传图谱上。遗传图谱和分子图谱是共线的，这种比对确定了朱红基因座控制区域的DNA位置。已鉴定出一种4.5kb的朱红RNA；其5'端位于控制区域内或附近。
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