骨髓基质细胞对造血干细胞的调控。
Regulation of hematopoietic stem cells by bone marrow stromal cells.
机构信息
Department of Medicine, Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA.
Department of Medicine, Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA.
出版信息
Trends Immunol. 2014 Jan;35(1):32-7. doi: 10.1016/j.it.2013.10.002. Epub 2013 Nov 5.
Abstract
Hematopoietic stem cells (HSCs) reside in specialized microenvironments (niches) in the bone marrow. The stem cell niche is thought to provide signals that support key HSC properties, including self-renewal capacity and long-term multilineage repopulation ability. The stromal cells that comprise the stem cell niche and the signals that they generate that support HSC function are the subjects of intense investigation. Here, we review the complex and diverse stromal cell populations that reside in the bone marrow and examine their contribution to HSC maintenance. We highlight recent data suggesting that perivascular chemokine CXC ligand (CXCL)12-expressing mesenchymal progenitors and endothelial cells are key cellular components of the stem cell niche in the bone marrow.
摘要
造血干细胞（HSCs）存在于骨髓中的特殊微环境（龛）中。干细胞龛被认为提供支持 HSC 关键特性的信号，包括自我更新能力和长期多谱系重编程能力。构成干细胞龛的基质细胞及其产生的支持 HSC 功能的信号是深入研究的主题。在这里，我们回顾了存在于骨髓中的复杂多样的基质细胞群体，并研究了它们对 HSC 维持的贡献。我们强调了最近的数据表明，血管周趋化因子 CXC 配体（CXCL）12 表达的间充质祖细胞和内皮细胞是骨髓中干细胞龛的关键细胞成分。
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