Department of Molecular Medicine, La Sapienza Universita' di Roma, Rome, Italy.
Nat Med. 2013 Jan;19(1):35-42. doi: 10.1038/nm.3028. Epub 2013 Jan 7.
Mesenchymal stem cells (MSCs) are the focus of intensive efforts worldwide directed not only at elucidating their nature and unique properties but also developing cell-based therapies for a diverse range of diseases. More than three decades have passed since the original formulation of the concept, revolutionary at the time, that multiple connective tissues could emanate from a common progenitor or stem cell retained in the postnatal bone marrow. Despite the many important advances made since that time, substantial ambiguities still plague the field regarding the nature, identity, function, mode of isolation and experimental handling of MSCs. These uncertainties have a major impact on their envisioned therapeutic use.
间充质干细胞（MSCs）是全球研究的重点，不仅旨在阐明其性质和独特特性，还开发针对多种疾病的基于细胞的治疗方法。自最初提出这一概念以来，已经过去了三十多年，当时的概念具有革命性，即多种结缔组织可以源自保留在出生后骨髓中的共同祖细胞或干细胞。尽管此后取得了许多重要进展，但关于 MSCs 的性质、身份、功能、分离方式和实验处理等方面仍存在很大的不确定性。这些不确定性对它们预期的治疗用途有重大影响。
