Wageningen University, Department of Human Nutrition, P.O. Box 8129, 6700 EV Wageningen, The Netherlands.
University of Bologna, Department of Experimental Diagnostic and Specialty Medicine, Via San Giacomo, 12, 40126 Bologna, Italy.
Mech Ageing Dev. 2013 Nov-Dec;134(11-12):523-30. doi: 10.1016/j.mad.2013.10.002. Epub 2013 Nov 5.
The proportion of European elderly is expected to increase to 30% in 2060. Combining dietary components may modulate many processes involved in ageing. So, it is likely that a healthful diet approach might have greater favourable impact on age-related decline than individual dietary components. This paper describes the design of a healthful diet intervention on inflammageing and its consequences in the elderly.
The NU-AGE study is a parallel randomized one-year trial in 1250 apparently healthy, independently living European participants aged 65-80 years. Participants are randomised into either the diet group or control group. Participants in the diet group received dietary advice aimed at meeting the nutritional requirements of the ageing population. Special attention was paid to nutrients that may be inadequate or limiting in diets of elderly, such as vitamin D, vitamin B12, and calcium. C-reactive protein is measured as primary outcome.
The NU-AGE study is the first dietary intervention investigating the effect of a healthful diet providing targeted nutritional recommendations for optimal health and quality of life in apparently healthy European elderly. Results of this intervention will provide evidence on the effect of a healthful diet on the prevention of age related decline.
预计到 2060 年，欧洲老年人的比例将增加到 30%。饮食成分的结合可能会调节许多与衰老有关的过程。因此，健康饮食的方法可能比单一的饮食成分对与年龄相关的衰退有更大的有利影响。本文描述了一项针对老年人炎症衰老及其后果的健康饮食干预的设计。
NU-AGE 研究是一项在 1250 名年龄在 65-80 岁、明显健康、独立生活的欧洲参与者中进行的平行随机一年期试验。参与者被随机分为饮食组或对照组。饮食组的参与者接受了旨在满足老年人口营养需求的饮食建议。特别注意那些在老年人饮食中可能不足或有限的营养素，如维生素 D、维生素 B12 和钙。C 反应蛋白是主要的观察结果。
NU-AGE 研究是第一项针对健康饮食的干预研究，该研究提供了针对明显健康的欧洲老年人的最佳健康和生活质量的有针对性的营养建议。该干预措施的结果将提供关于健康饮食对预防与年龄相关的衰退的影响的证据。
