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Thoracoscore能否预测接受肺切除术患者的术后死亡率?

Could Thoracoscore predict postoperative mortality in patients undergoing pneumonectomy?

作者信息

Qadri Syed S A, Jarvis Martin, Ariyaratnam Priyadharshanan, Chaudhry Mubarak A, Cale Alex R J, Griffin Steven, Cowen Michael E, Loubani Mahmoud

机构信息

Department of Cardiothoracic Surgery, Castle Hill Hospital, Cottingham, UK.

出版信息

Eur J Cardiothorac Surg. 2014 May;45(5):864-9. doi: 10.1093/ejcts/ezt517. Epub 2013 Nov 7.

Abstract

OBJECTIVES

Thoracoscore is incorporated in the new British Thoracic Society and National Institute of Health and clinical Excellence guidelines to evaluate the operative mortality risk of patients undergoing thoracic surgery. This study examines the accuracy of Thoracoscore in predicting postoperative mortality in patients undergoing pneumonectomy.

METHODS

All patients who underwent pneumonectomy from January 1998 to March 2008 were included. Thoracoscore was calculated based on the following variables: age, sex, American Society of Anaesthesiologists' class, performance status classification, dyspnoea score, priority of surgery, procedure class, Diagnosis group and comorbidities score.

RESULTS

Two hundred and forty-three patients with a mean age of 63 ± 9 years were included and 81% were male. The predicted postoperative mortality based on Thoracoscore was 8 ± 2.6% (95% confidence interval (CI) 4.56-11.43), while actual in-hospital mortality was 4.5% (11/243) (95% CI 1.87-7.12). 54% (6/11) of in-hospital mortality was of those who were >70 years old and 73% (8/11) of patients who died in hospital were male. Nine of 11 (82%) patients had pneumonectomy for malignancy. Thoracoscore was divided into four risk groups: low (0-3), moderate (3.1-5), high (5.1-8) and very high (>8). It underestimated mortality in low-risk group while overestimated in high-risk groups. The 30-day, 1-year, 2-year and 3-year observed mortalities were 5.3, 29, 43 and 55%, respectively.

CONCLUSIONS

Although advanced age, the male sex and malignancy proved to be strong predictors of in-hospital mortality in our study, Thoracoscore failed to predict accurate risk of in-hospital mortality in pneumonectomy patients in this study. Further studies are required to validate the Thoracoscore in different subgroups of thoracic surgery.

摘要

目的

胸科手术评分已纳入新的英国胸科学会和国家卫生与临床优化研究所指南,用于评估胸外科手术患者的手术死亡风险。本研究探讨胸科手术评分在预测肺叶切除患者术后死亡率方面的准确性。

方法

纳入1998年1月至2008年3月期间所有接受肺叶切除术的患者。胸科手术评分基于以下变量计算:年龄、性别、美国麻醉医师协会分级、体能状态分类、呼吸困难评分、手术优先级、手术类型、诊断组和合并症评分。

结果

纳入243例患者,平均年龄63±9岁,81%为男性。基于胸科手术评分预测的术后死亡率为8±2.6%(95%置信区间[CI]4.56 - 11.43),而实际住院死亡率为4.5%(11/243)(95%CI 1.87 - 7.12)。54%(6/11)的住院死亡患者年龄>70岁,73%(8/11)的住院死亡患者为男性。11例患者中有9例(82%)因恶性肿瘤接受肺叶切除术。胸科手术评分分为四个风险组:低(0 - 3)、中(3.1 - 5)、高(5.1 - 8)和极高(>8)。它在低风险组中低估了死亡率,而在高风险组中高估了死亡率。30天、1年、2年和3年的观察死亡率分别为5.3%、29%、43%和55%。

结论

尽管在我们的研究中高龄、男性和恶性肿瘤被证明是住院死亡率的强预测因素,但在本研究中胸科手术评分未能准确预测肺叶切除患者的住院死亡风险。需要进一步研究以验证胸科手术评分在胸外科不同亚组中的有效性。

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