Department of Cardiothoracic Surgery, Wythenshawe Hospital, Manchester University Hospital Foundation Trust, Manchester, UK.
Division of Informatics, Imaging and Data Science, Faculty of Biology, Medicine and Health, Manchester Academic Heath Science Centre, University of Manchester, Manchester, UK.
Interact Cardiovasc Thorac Surg. 2021 Apr 8;32(3):333-342. doi: 10.1093/icvts/ivaa273.
OBJECTIVES: Guidelines advocate that patients being considered for thoracic surgery should undergo a comprehensive preoperative risk assessment. Multiple risk prediction models to estimate the risk of mortality after thoracic surgery have been developed, but their quality and performance has not been reviewed in a systematic way. The objective was to systematically review these models and critically appraise their performance. METHODS: The Cochrane Library and the MEDLINE database were searched for articles published between 1990 and 2019. Studies that developed or validated a model predicting perioperative mortality after thoracic surgery were included. Data were extracted based on the checklist for critical appraisal and data extraction for systematic reviews of prediction modelling studies. RESULTS: A total of 31 studies describing 22 different risk prediction models were identified. There were 20 models developed specifically for thoracic surgery with two developed in other surgical specialties. A total of 57 different predictors were included across the identified models. Age, sex and pneumonectomy were the most frequently included predictors in 19, 13 and 11 models, respectively. Model performance based on either discrimination or calibration was inadequate for all externally validated models. The most recent data included in validation studies were from 2018. Risk of bias (assessed using Prediction model Risk Of Bias ASsessment Tool) was high for all except two models. CONCLUSIONS: Despite multiple risk prediction models being developed to predict perioperative mortality after thoracic surgery, none could be described as appropriate for contemporary thoracic surgery. Contemporary validation of available models or new model development is required to ensure that appropriate estimates of operative risk are available for contemporary thoracic surgical practice.
目的:指南主张,拟行胸外科手术的患者应接受全面的术前风险评估。已经开发出多种预测死亡率的风险预测模型来评估胸外科手术后的死亡风险,但尚未对其进行系统的质量和性能评估。本研究旨在系统地回顾这些模型并对其性能进行批判性评价。
方法:检索 Cochrane 图书馆和 MEDLINE 数据库,收集 1990 年至 2019 年发表的文章。纳入开发或验证预测胸外科围手术期死亡率模型的研究。根据预测模型研究的批判性评估和数据提取清单提取数据。
结果:共确定了 31 项描述 22 种不同风险预测模型的研究。其中 20 个模型是专门为胸外科开发的,另外两个是在其他外科专业开发的。在确定的模型中总共纳入了 57 个不同的预测因素。年龄、性别和全肺切除术是 19、13 和 11 个模型中最常包含的预测因素。所有经过外部验证的模型在基于区分度或校准度的模型性能评估方面均不理想。验证研究中纳入的最新数据来自 2018 年。除了两个模型外,所有模型的预测模型风险偏倚评估工具(Prediction model Risk Of Bias ASsessment Tool)评估风险均较高。
结论:尽管已经开发了多种预测胸外科手术后围手术期死亡率的风险预测模型,但没有一个模型可以被描述为适用于当代胸外科手术。需要对现有的模型进行当代验证或开发新的模型,以确保为当代胸外科实践提供适当的手术风险估计。
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