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胸腔镜评分和欧洲协会客观评分无法预测英国患者的死亡率。

Thoracoscore and European Society Objective Score Fail to Predict Mortality in the UK.

作者信息

Sharkey Annabel, Ariyaratnam Priyadharshanan, Anikin Vladimir, Belcher Elizabeth, Kendall Simon, Lim Eric, Naidu Babu, Parry Wyn, Loubani Mahmoud

机构信息

Department of Cardiothoracic Surgery, Castle Hill Hospital, Hull, HU16 5JQ, UK.

Department of Thoracic Surgery, Harefield Hospital Hill End Road, Harefield, Middlesex UB9 6JH, UK.

出版信息

World J Oncol. 2015 Feb;6(1):270-275. doi: 10.14740/wjon897w. Epub 2015 Feb 14.

Abstract

BACKGROUND

Thoracoscore and the European Society Objective Score (ESOS.01) are two scoring systems used in thoracic surgery to estimate operative mortality risk. We aimed to evaluate if these are valid tools for use in the UK population.

METHODS

A multi-center, prospective study was carried out on patients undergoing lung resection at six UK centers. Data were submitted electronically using our online data collection tool. Data were analyzed to determine the factors affecting mortality. A receiver operating characteristic analysis determined the ability of the thoracoscore and ESOS.01 to predict in-hospital mortality.

RESULTS

Data were complete for 2,245 patients. The observed in-hospital mortality was 31 patients (1.38%). Mean thoracoscore was 2.66 (SD ± 3.21). Gender (P = 0.004, hazard ratio 4.786) and co-morbidity score (P = 0.005, hazard ratio 3.289) were identified as risk factors for mortality. A sub-analysis was performed using data from 1,912 patients with complete data for ESOS.01. In this group, mean thoracoscore was 2.55 (SD ± 2.94), mean ESOS.01 was 2.11(SD ± 1.41), and these were statistically significantly different (P < 0.0001). The observed in-hospital mortality was 28 patients (1.46%). The c-index for thoracoscore was 0.705, and for ESOS.01 was 0.739.

CONCLUSIONS

Both thoracoscore and ESOS.01 overestimated mortality in the UK population. There is a continued need to develop an appropriate risk prediction system for the UK.

摘要

背景

胸科手术评分(Thoracoscore)和欧洲协会客观评分(ESOS.01)是胸外科用于评估手术死亡风险的两种评分系统。我们旨在评估它们是否适用于英国人群。

方法

在英国六个中心对接受肺切除术的患者进行了一项多中心前瞻性研究。使用我们的在线数据收集工具以电子方式提交数据。分析数据以确定影响死亡率的因素。通过受试者工作特征分析确定胸科手术评分和ESOS.01预测住院死亡率的能力。

结果

2245例患者的数据完整。观察到的住院死亡率为31例患者(1.38%)。胸科手术评分的平均值为2.66(标准差±3.21)。性别(P = 0.004,风险比4.786)和合并症评分(P = 0.005,风险比3.289)被确定为死亡风险因素。使用1912例ESOS.01数据完整患者的数据进行了亚组分析。在该组中,胸科手术评分的平均值为2.55(标准差±2.94),ESOS.01的平均值为2.11(标准差±1.41),且这些差异具有统计学意义(P < 0.0001)。观察到的住院死亡率为28例患者(1.46%)。胸科手术评分的c指数为0.705,ESOS.01的c指数为0.739。

结论

胸科手术评分和ESOS.01均高估了英国人群的死亡率。持续需要为英国开发合适的风险预测系统。

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