Laboratory of Developmental Biology and Genomics, College of Veterinary Medicine, Research Institute for Veterinary Science, Brain Korea 21 Program for Veterinary Science, Seoul, Korea.
Mol Cells. 2013 Nov;36(5):472-5. doi: 10.1007/s10059-013-0249-9. Epub 2013 Nov 8.
Epigenetic modifications affect gene expression and thereby govern a wide range of biological processes such as differentiation, development and tumorigenesis. Recent initiatives to define genome-wide DNA methylation and histone modification profiles by microarray and sequencing methods have led to the construction of databases. These databases are repositories for international epigenetic consortiums or provide mining results from PubMed, but do not integrate the epigenetic information with gene expression changes. In order to overcome this limitation, we constructed EPITRANS, a novel database that visualizes the relationships between gene expression and epigenetic modifications. EPITRANS uses combined analysis of epigenetic modification and gene expression to search for cell function-related epigenetic and transcriptomic alterations (Freely available on the web at http://epitrans.org ).
表观遗传修饰影响基因表达，从而调控多种生物学过程，如分化、发育和肿瘤发生。最近通过微阵列和测序方法定义全基因组 DNA 甲基化和组蛋白修饰图谱的举措，导致了数据库的构建。这些数据库是国际表观遗传学联盟的存储库，或者提供来自 PubMed 的挖掘结果，但没有将表观遗传信息与基因表达变化整合在一起。为了克服这一限制，我们构建了 EPITRANS，这是一个新颖的数据库，可直观显示基因表达和表观遗传修饰之间的关系。EPITRANS 使用表观遗传修饰和基因表达的联合分析来搜索与细胞功能相关的表观遗传和转录组改变（可在 http://epitrans.org 上免费获得）。
