Konecka A M, Sroczynska I, Przewlocki R
Arch Int Physiol Biochim. 1985 Nov;93(4):279-84. doi: 10.3109/13813458509079607.
Pain sensitivity of food and/or water-deprived male mice was tested on a hotplate. The most pronounced analgesia ensued in animals given no food and water, and no food but water ad libitum, the least one in water-deprived mice. The magnitude of the rise in pain threshold depended on the duration of deprivation and was correlated with the increase in the blood plasma beta-endorphin level. In the hypothalamus beta-endorphin level increased after 72-h food deprivation only. The level of dynorphin remained unchanged. Naloxone (10 mg/kg) almost completely reversed food or water-deprivation induced analgesia.
在热板上测试了食物和/或水剥夺雄性小鼠的疼痛敏感性。最显著的镇痛效果出现在既不给食物也不给水以及不给食物但随意给水的动物身上，而在水剥夺小鼠中镇痛效果最差。痛阈升高的幅度取决于剥夺的持续时间，并且与血浆β-内啡肽水平的升高相关。仅在72小时食物剥夺后，下丘脑β-内啡肽水平升高。强啡肽水平保持不变。纳洛酮（10毫克/千克）几乎完全逆转了食物或水剥夺诱导的镇痛作用。
