Maries Lorena, Manitiu Ioan
Lucian Blaga University, Sibiu, Romania.
Cardiovasc J Afr. 2013 Aug;24(7):286-9. doi: 10.5830/CVJA-2013-055.
B-type natriuretic peptide (BNP) is a member of a fournatriuretic peptide family that shares a common 17-peptide ring structure. The N-terminal fragment (NT-pro-BNP) is biologically inert, but both are secreted in the plasma in equimolar quantities and both have been evaluated for use in the management of congestive heart failure. BNP and NT-pro-BNP are frequently used in the diagnosis of congestive heart failure and distinguishing between patients with dyspnoea of cardiac or pulmonary origin. Values of NT-pro-BNP are affected by age or the presence of one or several co-morbidities such as chronic renal failure, type 2 diabetes, and acute coronary syndrome. 'Normal' values of these peptides also vary depending on the type of test used. The performance characteristics of these tests vary depending on the patients on whom they are used and the manufacturer. For this reason, the determination of reference values for this peptide represents such a challenge.
B型利钠肽（BNP）是利钠肽家族的一员，该家族具有共同的17肽环结构。N端片段（NT-pro-BNP）无生物活性，但二者均以等摩尔量分泌入血浆，且都已被评估用于充血性心力衰竭的管理。BNP和NT-pro-BNP常用于充血性心力衰竭的诊断以及鉴别心源性或肺源性呼吸困难患者。NT-pro-BNP的值受年龄或一种或多种合并症（如慢性肾衰竭、2型糖尿病和急性冠脉综合征）的影响。这些肽的“正常”值也因所用检测类型而异。这些检测的性能特征因使用对象和制造商的不同而有所差异。因此，确定该肽的参考值是一项挑战。
