Moschou Panagiotis N, Roubelakis-Angelakis Kalliopi A
Department of Plant Biology and Forest Genetics, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, 75007 Uppsala, Sweden.
J Exp Bot. 2014 Mar;65(5):1285-96. doi: 10.1093/jxb/ert373. Epub 2013 Nov 11.
Polyamines (PAs) have been considered as important molecules for survival. However, evidence reinforces that PAs are also implicated, directly or indirectly, in pathways regulating programmed cell death (PCD). Direct correlation of PAs with cell death refers to their association with particular biological processes, and their physical contact with molecules or structures involved in cell death. Indirectly, PAs regulate PCD through their metabolic derivatives, such as catabolic and interconversion products. Cytotoxic products of PA metabolism are involved in PCD cascades, whereas it remains largely elusive how PAs directly control pathways leading to PCD. In this review, we present and compare advances in PA-dependent PCD in animals and plants.
多胺（PAs）被认为是生存所必需的重要分子。然而，有证据进一步表明，PAs也直接或间接地参与调节程序性细胞死亡（PCD）的信号通路。PAs与细胞死亡的直接关联是指它们与特定生物学过程的联系，以及与参与细胞死亡的分子或结构的物理接触。间接而言，PAs通过其代谢衍生物（如分解代谢产物和相互转化产物）来调节PCD。PA代谢的细胞毒性产物参与PCD级联反应，而PAs如何直接控制导致PCD的信号通路在很大程度上仍不清楚。在本综述中，我们展示并比较了动物和植物中PA依赖的PCD的研究进展。
