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塞来昔布用于髋关节镜手术后疼痛管理的疗效:一项前瞻性随机安慰剂对照研究。

Efficacy of celecoxib for pain management after arthroscopic surgery of hip: a prospective randomized placebo-controlled study.

作者信息

Zhang Zhenxiang, Zhu Wei, Zhu Lixian, Du Yaqing

机构信息

Orthopedic Department, The Affiliated Taizhou People's Hospital of Nantong University, Taizhou, 225300, Jiangsu, People's Republic of China,

出版信息

Eur J Orthop Surg Traumatol. 2014 Aug;24(6):919-23. doi: 10.1007/s00590-013-1359-y. Epub 2013 Nov 13.

Abstract

The present work was conducted to examine whether celecoxib, a selective COX-2 inhibitor, 200 mg administered 1 h preoperatively to patients undergoing arthroscopic hip surgery reduces postoperative pain. Fifty-three patients undergoing arthroscopic hip surgery under spinal anesthesia were randomized to receive either 200 mg of celecoxib (Group I) or 200 mg of placebo (Group II) 1 h preoperatively. Narcotic use was monitored for 24 h, and time in recovery room was determined. Visual analog scale (VAS) scores and Short-Form 12 (SF-12), including a physical composite score (PCS) and a mental composite score (MCS), documented pain in recovery, 12 h postoperatively, and 24 h postoperatively. Moreover, time in recovery room was also investigated. We enrolled 27 patients in Group I and 26 patients in Group II. Groups were comparable for patient characteristics. No significant difference was detected in terms of VAS scores and SF-12 in recovery room. Statistically, patients in Group I showed significantly lower pain VAS scores at 12 and 24 h postoperatively. Patients taking celecoxib had significantly higher PCS at 12 and 24 h postoperatively. No difference occurred between groups for the MCS. Patients taking celecoxib also showed a significant reduction in postoperative narcotic consumption. The obtained results from the current study indicate that patients who took celecoxib 200 mg 1 h before arthroscopic hip surgery had a less painful and more rapid recovery. Celecoxib 200 mg as a single preoperative dose could be considered as part of a perioperative analgesic plan in arthroscopic hip surgery.

摘要

本研究旨在探讨选择性环氧化酶-2(COX-2)抑制剂塞来昔布,于髋关节镜手术患者术前1小时给予200mg,是否能减轻术后疼痛。53例接受脊髓麻醉下行髋关节镜手术的患者被随机分为两组,术前1小时分别给予200mg塞来昔布(I组)或200mg安慰剂(II组)。监测24小时内的麻醉药物使用情况,并确定在恢复室的停留时间。采用视觉模拟评分法(VAS)和简明健康调查问卷12项版本(SF-12),包括身体综合评分(PCS)和精神综合评分(MCS),记录患者在恢复室、术后12小时和24小时的疼痛情况。此外,还对在恢复室的停留时间进行了调查。I组纳入27例患者,II组纳入26例患者。两组患者的特征具有可比性。在恢复室,两组患者的VAS评分和SF-12评分无显著差异。统计学分析显示,I组患者在术后12小时和24小时的疼痛VAS评分显著较低。服用塞来昔布的患者在术后12小时和24小时的PCS显著较高。两组患者的MCS无差异。服用塞来昔布的患者术后麻醉药物消耗量也显著减少。本研究结果表明,髋关节镜手术前1小时服用200mg塞来昔布的患者疼痛较轻,恢复更快。200mg塞来昔布作为术前单次剂量可被视为髋关节镜手术围手术期镇痛方案的一部分。

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