Akram Yusup, Hai-Jiang Wang, Azmat Rahmutula, Parhat Sayim, Ze-Liang Zhao, Guo-Qing Zhang, Department of Gastrointestinal Surgery, Xin Jiang Tumor Hospital, Xin Jiang Medical University, Urumqi 830011, Xinjiang Uighur Autonomous Region, China.
World J Gastroenterol. 2013 Nov 7;19(41):7183-8. doi: 10.3748/wjg.v19.i41.7183.
To compare the clinical factors and tumor characteristics that predict survival in colorectal cancer (CRC) patients with different ethnicities in Xin Jiang area.
A total of 1421 histopathologically confirmed sporadic CRC patients who were either Han/Chinese or Uyghur were identified and enrolled from a database of both diagnoses and operative procedures from Xin Jiang Tumor Hospital, which is affiliated to Xin Jiang Medical University between 2000 and 2007. Patients with family histories of CRC, hereditary nonpolyposis CRC, familial adenomatous polyposis, inflammatory bowel disease, carcinoid, squamous carcinoma or melanoma were excluded. The two ethnic groups were compared with regard to clinical features, tumor characteristics, disease stage, overall survival rate, disease-free survival rate and cancer-specific survival rate. The factors predicting long-term survival were assessed via both univariate and multivariate analysis.
Among the 1421 patients with CRC enrolled in this study, 1210 patients were Han/Chinese (mean age, 62.3 ± 4.5 years; range, 19-92 years), while 211 patients were Uyghur (mean age, 52.4 ± 15.6 years; range, 17-87 years). There were significant differences in proportions of gender, age, blood type, occupation and histopathological type between the Han/Chinese and Uyghur patients (P < 0.05). The median overall, disease-free and cancer-specific survival time were 45, 62 and 65 mo for the Han/Chinese patients and 42, 49 and 61 mo for the Uyghur patients (P = 0.000, P = 0.005, P = 0.007). The cumulative 5-year survival of the Uyghur patients was significantly worse than that of the Han patients (P = 0.000). A multivariate analysis showed that age, ethnicity, histopathological type, differentiation, T (Infiltration depth), N (Lymph node metastasis), staging, postoperative metastasis and metastatic site (P < 0.05) were found to be the prognostic factors.
The Uyghur CRC patients are associated with significantly younger age, more aggressive histopathologic characteristics and have significantly worse prognosis than the Han/Chinese patients.
比较新疆地区不同民族结直肠癌（CRC）患者的临床因素和肿瘤特征，以预测其生存情况。
本研究纳入了 2000 年至 2007 年期间，新疆医科大学附属肿瘤医院的诊断和手术数据库中 1421 例经组织病理学证实的散发性 CRC 患者，这些患者均为汉族或维吾尔族。排除有 CRC 家族史、遗传性非息肉病性 CRC、家族性腺瘤性息肉病、炎症性肠病、类癌、鳞状细胞癌或黑色素瘤的患者。比较了两组患者的临床特征、肿瘤特征、疾病分期、总生存率、无病生存率和癌症特异性生存率。通过单因素和多因素分析评估了预测长期生存的因素。
本研究共纳入 1421 例 CRC 患者，其中汉族 1210 例（平均年龄 62.3±4.5 岁，范围 19-92 岁），维吾尔族 211 例（平均年龄 52.4±15.6 岁，范围 17-87 岁）。汉族和维吾尔族患者在性别、年龄、血型、职业和组织病理学类型方面存在显著差异（P<0.05）。汉族患者的中位总生存、无病生存和癌症特异性生存时间分别为 45、62 和 65 个月，维吾尔族患者分别为 42、49 和 61 个月（P=0.000、P=0.005、P=0.007）。维吾尔族患者的 5 年累积生存率明显低于汉族患者（P=0.000）。多因素分析显示，年龄、民族、组织病理学类型、分化程度、T（浸润深度）、N（淋巴结转移）、分期、术后转移和转移部位（P<0.05）是预后因素。
维吾尔族 CRC 患者的年龄较小，组织病理学特征更为侵袭性，预后明显差于汉族患者。
