Fa-Ming Zhang, Hong-Gang Wang, Min Wang, Bo-Ta Cui, Zhi-Ning Fan, Guo-Zhong Ji, Digestive Endoscopy and Medical Center for Digestive Diseases, the Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, Jiangsu Province, China.
World J Gastroenterol. 2013 Nov 7;19(41):7213-6. doi: 10.3748/wjg.v19.i41.7213.
The concept of fecal microbiota transplantation (FMT) has been used in traditional Chinese medicine at least since the 4(th) century. Evidence from recent human studies strongly supports the link between intestinal bacteria and inflammatory bowel disease. We proposed that standardized FMT might be a promising rescue therapy for refractory inflammatory bowel disease. However, there were no reports of FMT used in patients with severe Crohn's disease (CD). Here, we report the successful treatment of standardized FMT as a rescue therapy for a case of refractory CD complicated with fistula, residual Barium sulfate and formation of intraperitoneal large inflammatory mass. As far as we know, this is the first case of severe CD treated using FMT through mid-gut.
粪便微生物移植（FMT）的概念至少在 4 世纪就已在中国传统医学中使用。最近的人类研究证据强烈支持肠道细菌与炎症性肠病之间的联系。我们提出，标准化的 FMT 可能是治疗难治性炎症性肠病的一种有前途的抢救疗法。然而，目前还没有关于 FMT 在严重克罗恩病（CD）患者中应用的报道。在这里，我们报告了标准化 FMT 作为一种抢救疗法治疗难治性 CD 合并瘘管、钡残留和腹腔内大炎性肿块的成功案例。据我们所知，这是首例通过中肠进行 FMT 治疗的严重 CD 病例。
