Boicean Adrian, Bratu Dan, Bacila Ciprian, Tanasescu Ciprian, Fleacă Radu Sorin, Mohor Calin Ilie, Comaniciu Andra, Băluță Teodora, Roman Mihai Dan, Chicea Radu, Cristian Adrian Nicolae, Hasegan Adrian, Birsan Sabrina, Dura Horațiu, Mohor Cosmin Ioan
County Clinical Emergency Hospital of Sibiu, 550245 Sibiu, Romania.
Faculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, Romania.
Pathogens. 2023 May 26;12(6):766. doi: 10.3390/pathogens12060766.
In a mutually beneficial connection with its host, the gut microbiota affects the host's nutrition, immunity, and metabolism. An increasing number of studies have shown links between certain types of disease and gut dysbiosis or specific microorganisms. Fecal microbiota transplantation (FMT) is strongly advised for the treatment of recurrent or resistant Clostridium difficile infection (CDI) due to its outstanding clinical effectiveness against CDI. The therapeutic potential of FMT for other disorders, particularly inflammatory bowel diseases and malignancies, is currently gaining more and more attention. We summarized the most recent preclinical and clinical evidence to show the promise of FMT in the management of cancer as well as complications related to cancer treatment after reviewing the most recent research on the gut microbiota and its relationship to cancer.
肠道微生物群与其宿主建立了互利关系，影响宿主的营养、免疫和代谢。越来越多的研究表明，某些类型的疾病与肠道微生物失调或特定微生物之间存在联系。粪便微生物群移植（FMT）因其对艰难梭菌感染（CDI）具有显著的临床疗效，被强烈推荐用于治疗复发性或难治性CDI。目前，FMT对其他疾病，尤其是炎症性肠病和恶性肿瘤的治疗潜力越来越受到关注。在回顾了关于肠道微生物群及其与癌症关系的最新研究后，我们总结了最新的临床前和临床证据，以展示FMT在癌症管理以及癌症治疗相关并发症方面的前景。
