Chetram Mahandranauth A, Hinton Cimona V
Center for Cancer Research and Therapeutic Development, Clark Atlanta University, Atlanta, GA, 30314, USA.
Front Biol (Beijing). 2013 Jun 1;8(3). doi: 10.1007/s11515-012-1204-4.
Oxidative stress and the accumulation of reactive oxygen species (ROS) play a role in cancer cells developing an advanced, phenotypic signature that associates with metastasis and progression. Increased ROS concentrations are involved in promoting cancer development and metastasis by inducing expression of oncogenes, suppressing activity of anti-survival molecules and by activating various cell survival and proliferation signaling pathways. Oxidative stress is higher in the epithelium of cancer patients than patients without the disease, and antioxidant trials are currently being explored as a therapeutic option. However, studies have shown that ROS increases expression of CXCR4 in cancer and immune cells. CXCR4 expression in tumors strongly correlates to metastasis and poor prognosis. Herein, we discuss an emerging relationship between ROS and CXCR4 in cancer cells.
氧化应激和活性氧（ROS）的积累在癌细胞形成与转移和进展相关的晚期表型特征中发挥作用。ROS浓度升高通过诱导癌基因表达、抑制抗生存分子活性以及激活各种细胞存活和增殖信号通路，参与促进癌症发展和转移。癌症患者上皮组织中的氧化应激高于无病患者，目前正在探索将抗氧化剂试验作为一种治疗选择。然而，研究表明ROS会增加癌症和免疫细胞中CXCR4的表达。肿瘤中CXCR4的表达与转移和不良预后密切相关。在此，我们讨论癌细胞中ROS与CXCR4之间的一种新关系。
