Fenske Nora, Burns Jacob, Hothorn Torsten, Rehfuess Eva A
Institut für Statistik, Ludwig-Maximilians-Universität München, Munich, Germany.
PLoS One. 2013 Nov 4;8(11):e78692. doi: 10.1371/journal.pone.0078692. eCollection 2013.
Most attempts to address undernutrition, responsible for one third of global child deaths, have fallen behind expectations. This suggests that the assumptions underlying current modelling and intervention practices should be revisited.
We undertook a comprehensive analysis of the determinants of child stunting in India, and explored whether the established focus on linear effects of single risks is appropriate.
Using cross-sectional data for children aged 0-24 months from the Indian National Family Health Survey for 2005/2006, we populated an evidence-based diagram of immediate, intermediate and underlying determinants of stunting. We modelled linear, non-linear, spatial and age-varying effects of these determinants using additive quantile regression for four quantiles of the Z-score of standardized height-for-age and logistic regression for stunting and severe stunting.
At least one variable within each of eleven groups of determinants was significantly associated with height-for-age in the 35% Z-score quantile regression. The non-modifiable risk factors child age and sex, and the protective factors household wealth, maternal education and BMI showed the largest effects. Being a twin or multiple birth was associated with dramatically decreased height-for-age. Maternal age, maternal BMI, birth order and number of antenatal visits influenced child stunting in non-linear ways. Findings across the four quantile and two logistic regression models were largely comparable.
Our analysis confirms the multifactorial nature of child stunting. It emphasizes the need to pursue a systems-based approach and to consider non-linear effects, and suggests that differential effects across the height-for-age distribution do not play a major role.
营养不良导致全球三分之一的儿童死亡,多数解决营养不良问题的努力未达预期。这表明当前建模和干预实践所依据的假设应重新审视。
我们对印度儿童发育迟缓的决定因素进行了全面分析,并探讨了既定的对单一风险线性影响的关注是否恰当。
利用2005/2006年印度全国家庭健康调查中0至24个月儿童的横断面数据,我们构建了一个基于证据的发育迟缓直接、中间和根本决定因素的图表。我们使用年龄别身高Z评分的四个分位数的加法分位数回归以及发育迟缓和严重发育迟缓的逻辑回归,对这些决定因素的线性、非线性、空间和年龄变化影响进行建模。
在35%Z评分分位数回归中,十一组决定因素中的每组至少有一个变量与年龄别身高显著相关。不可改变的风险因素儿童年龄和性别,以及保护因素家庭财富、母亲教育程度和体重指数显示出最大的影响。双胞胎或多胞胎与年龄别身高显著降低有关。母亲年龄、母亲体重指数、出生顺序和产前检查次数以非线性方式影响儿童发育迟缓。四个分位数模型和两个逻辑回归模型的结果在很大程度上具有可比性。
我们的分析证实了儿童发育迟缓的多因素性质。它强调需要采用基于系统的方法并考虑非线性影响,并表明年龄别身高分布的差异影响不起主要作用。