Hill T L, Eisenberg E, Chalovich J M
Biophys J. 1981 Jul;35(1):99-112. doi: 10.1016/S0006-3495(81)84777-7.
Recent theoretical work on the cooperative equilibrium binding of myosin subfragment-1-ADP to regulated actin, as influenced by Ca2+, is extended here to the cooperative steady-state ATPase activity of myosin subfragment-1 on regulated actin. Exact solution of the general steady-state problem will require Monte Carlo calculations. Three interrelated special cases are discussed in some detail and sample computer (not Monte Carlo) solutions are given. The eventual objective is to apply these considerations to in vitro experimental data and to in vivo muscle models.
近期有关肌球蛋白亚片段-1-ADP与受Ca2+影响的调节性肌动蛋白的协同平衡结合的理论研究,在此扩展至肌球蛋白亚片段-1在调节性肌动蛋白上的协同稳态ATP酶活性。一般稳态问题的精确解需要蒙特卡罗计算。本文详细讨论了三个相互关联的特殊情况,并给出了示例计算机(非蒙特卡罗)解。最终目标是将这些考量应用于体外实验数据和体内肌肉模型。