Hill T L
Proc Natl Acad Sci U S A. 1985 Jul;82(13):4404-8. doi: 10.1073/pnas.82.13.4404.
A possible model is analyzed for the maintenance of attachment of a shortening microtubule (MT) to a kinetochore. In this model it is assumed that a MT is inserted and held in a sleeve or channel of the outer layer of a kinetochore while subunits are lost from the MT tip through the central layer of the kinetochore. A second problem considered is the elementary bioenergetics of MT growth and shortening, as associated with the presence or absence of a GTP cap on the MT ends. The free-energy source is the hydrolysis of GTP in solution. The third problem discussed is the kinetics of capture of a centrosomal MT by a target (e.g., a kinetochore).
分析了一种关于缩短的微管（MT）与动粒保持附着的可能模型。在该模型中，假设微管插入并固定在动粒外层的套筒或通道中，同时亚基从微管尖端通过动粒的中心层丢失。考虑的第二个问题是微管生长和缩短的基本生物能量学，这与微管末端是否存在GTP帽有关。自由能来源是溶液中GTP的水解。讨论的第三个问题是中心体微管被靶标（如动粒）捕获的动力学。
