局部用非甾体类抗炎药治疗黄斑水肿。
Topical nonsteroidal anti-inflammatory drugs for macular edema.
机构信息
Eye Clinic, Department of Neurological and Vision Sciences, University of Brescia, Piazzale Spedale Civili 1, 25123 Brescia, Italy.
出版信息
Mediators Inflamm. 2013;2013:476525. doi: 10.1155/2013/476525. Epub 2013 Oct 21.
Abstract
Nonsteroidal anti-inflammatory drugs (NSAIDs) are nowadays widely used in ophthalmology to reduce eye inflammation, pain, and cystoid macular edema associated with cataract surgery. Recently, new topical NSAIDs have been approved for topical ophthalmic use, allowing for greater drug penetration into the vitreous. Hence, new therapeutic effects can be achieved, such as reduction of exudation secondary to age-related macular degeneration or diabetic maculopathy. We provide an updated review on the clinical use of NSAIDs for retinal diseases, with a focus on the potential future applications.
摘要
如今，非甾体类抗炎药（NSAIDs）在眼科中广泛用于减轻白内障手术后的眼部炎症、疼痛和囊样黄斑水肿。最近，新的局部用 NSAIDs 已被批准用于眼部局部使用，从而使药物更深入地渗透到玻璃体中。因此，可以实现新的治疗效果，例如减少与年龄相关性黄斑变性或糖尿病性黄斑病变相关的渗出。我们提供了关于 NSAIDs 治疗视网膜疾病的临床应用的最新综述，重点介绍了潜在的未来应用。
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Br J Ophthalmol. 2013 Oct;97(10):1273-6. doi: 10.1136/bjophthalmol-2013-303417. Epub 2013 Jul 19.
2
Exploratory analysis of the effect of intravitreal ranibizumab or triamcinolone on worsening of diabetic retinopathy in a randomized clinical trial.一项随机临床试验中玻璃体内雷珠单抗或曲安奈德对糖尿病视网膜病变恶化影响的探索性分析。
JAMA Ophthalmol. 2013 Aug;131(8):1033-40. doi: 10.1001/jamaophthalmol.2013.4154.
3
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Br J Ophthalmol. 2013 Jul;97(7):862-5. doi: 10.1136/bjophthalmol-2012-302995. Epub 2013 Apr 23.
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7
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9
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