Zhang Yao, Hua Jin-Wei, Wang Xiu-Yan, Cheng Wen-Liang, Lei Hou-Xing, Cheng Ke-Jun, Yu Pei-Zhong
School of Pharmacy, Fudan Univerisity, Shanghai 201203, China.
Zhongguo Zhong Yao Za Zhi. 2013 Aug;38(16):2661-4.
To explore anti-tumor active components of Chimonanthus salicifolius, the phytochemistry of the chloroform fraction from leaves extract was investigated by repeated silica gel column chromatography. Twelve compounds were isolated and their structures were identified by physicochemical properties and spectroscopic data analysis as 9-epi-blumenol C(1), blumenol C(2), (+)-dehydrovomifoliol (3), (+)-vomifoliol (4), robinlin (5), (-)-loliolide (6), isofraxidin (7), scopoletin (8), 6,7-dimethoxycoumarin (9), 6, 7, 8-trimethoxycoumarin (10), beta-sitostenone (11), and beta-stigmasterol(12). Compounds 1-6 belonging to nor-sesquiterpenoids were isolated from the family Calycanthaceae for the first time. Compound 1 was a new natural product. Compounds 7, 11 and 12 were obtained from this plant for the first time.
为探索柳叶蜡梅的抗肿瘤活性成分，通过反复硅胶柱色谱法对叶提取物氯仿部位的植物化学进行了研究。分离得到12个化合物，通过理化性质和光谱数据分析确定其结构分别为9-表-布卢门醇C（1）、布卢门醇C（2）、（+）-脱氢vomifoliol（3）、（+）-vomifoliol（4）、robinlin（5）、（-）-洛里内酯（6）、异秦皮啶（7）、东莨菪内酯（8）、6,7-二甲氧基香豆素（9）、6,7,8-三甲氧基香豆素（10）、β-谷甾烷酮（11）和β-谷甾醇（12）。化合物1-6属于降倍半萜类，首次从蜡梅科植物中分离得到。化合物1为新天然产物。化合物7、11和12首次从该植物中获得。
