School of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, China.
Department of Drug Production Supervision and Administration, Jiangxi Medical Products Administration, Nanchang 330029, China.
J Asian Nat Prod Res. 2023 Jan;25(1):53-60. doi: 10.1080/10286020.2022.2058932. Epub 2022 Apr 21.
Two new sesquiterpenoids ( and ), one new natural product (), and two known compounds ( and ) were isolated from the leaves of . Their structures were elucidated by spectroscopic analysis, and the absolute configuration of compound was determined by the X-ray single-crystal diffraction analysis. The cytotoxicity of compounds was evaluated at three concentrations on two human breast cancer cell lines (MDA-MB-468 and MDA-MB-231) by MTT assay. As a result, we found that the cytotoxicity was weak even with a concentration of these compounds up to 100 μM.
从 叶片中分离得到两个新的倍半萜（和），一个新的天然产物（）和两个已知化合物（和）。通过光谱分析阐明了它们的结构，并通过 X 射线单晶衍射分析确定了化合物的绝对构型。采用 MTT 法测定了化合物在两种人乳腺癌细胞系（MDA-MB-468 和 MDA-MB-231）上三个浓度下的细胞毒性。结果表明，即使在这些化合物浓度高达 100μM 的情况下，细胞毒性也很弱。
