School of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, China.
Jiangxi province food and drug adminstration, Nanchang 330029, China.
Fitoterapia. 2021 Oct;154:105019. doi: 10.1016/j.fitote.2021.105019. Epub 2021 Aug 14.
Six new cadinane-type sesquiterpenoids, named Chimnitensin A-F (1-6) were isolated from the leaves of Chimonanthus nitens Oliv. Their structures were elucidated by comprehensive spectroscopic analyses and comparison with structurally related known analogues. In vitro MTT assay showed that all six compounds had cytotoxicity against two selected human breast cancer cell lines (MDA-MB-468 and MDA-MB-231), which indicate their potential of developing into anticancer drugs.
从蜡梅科蜡梅属植物夏蜡梅的叶子中分离得到了 6 个新的贝壳杉烷型倍半萜，分别命名为 Chimnitensin A-F（1-6）。通过综合光谱分析和与结构相关的已知类似物进行比较，确定了它们的结构。体外 MTT 试验表明，这 6 个化合物对两种选定的人乳腺癌细胞系（MDA-MB-468 和 MDA-MB-231）均具有细胞毒性，表明它们具有开发成抗癌药物的潜力。
