重度间歇性饮酒与酒精相关损伤之间的关联：病例对照研究。
Associations between heavy episodic drinking and alcohol related injuries: a case control study.
机构信息
Norwegian Institute for Alcohol and Drug Research, POB 565 Sentrum, Oslo N-0105, Norway.
出版信息
BMC Public Health. 2013 Nov 14;13:1076. doi: 10.1186/1471-2458-13-1076.
BACKGROUND
Alcohol is a significant risk factor for injuries. This study addresses 1) whether the risk of alcohol related injury increases with frequency of heavy episodic drinking (HED) in a linear fashion, and 2) whether a small group of high risk drinkers accounts for the majority of alcohol related injuries.
METHODS
We applied a case - control design. Cases were BAC positive injured patients (n = 534) and controls were respondents to a general population survey in Norway (n = 1947). Age and gender adjusted association between self-reported past year HED frequency and alcohol related injury risk was estimated in logistic regression models for all alcohol related injuries and for violence injuries and accident injuries separately.
RESULTS
An increase in HED was associated with an increase in risk of alcohol related injury, resembling a linear risk function. The small fraction of high risk drinkers (6.6%) accounted for 41.6% of all alcohol related injuries, thus lending support to the validity of the prevention paradox.
CONCLUSION
There is a strong relationship between frequency of heavy episodic drinking and risk of alcohol related injuries, yet the majority of alcohol related injuries are found among drinkers who are not in the high risk group.
背景
酒精是导致伤害的一个重要危险因素。本研究旨在探讨以下两个问题：1）在重度间歇性饮酒（HED）频率呈线性增加的情况下，酒精相关损伤的风险是否会增加；2）少数高风险饮酒者是否会导致大多数酒精相关损伤。
方法
我们采用病例对照设计。病例组为 BAC 阳性受伤患者（n=534），对照组为挪威一般人群调查的应答者（n=1947）。在逻辑回归模型中，对所有酒精相关损伤以及暴力损伤和意外损伤分别进行了年龄和性别调整，以评估过去一年 HED 频率与酒精相关损伤风险之间的关联。
结果
HED 的增加与酒精相关损伤风险的增加相关，呈现出线性风险函数。少数高风险饮酒者（6.6%）占所有酒精相关损伤的 41.6%，这支持了预防悖论的有效性。
结论
重度间歇性饮酒的频率与酒精相关损伤的风险之间存在很强的关系，但大多数酒精相关损伤发生在不属于高风险组的饮酒者中。
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