Roncoroni L, De Bernardinis M, Violi V, Montanari M, Peracchia A
Am J Gastroenterol. 1986 Jun;81(6):432-5.
Twenty patients undergoing sphincteroplasty for cholelithiasis were randomly divided into two groups of 10. The former (T) were treated with a 4-h somatostatin intravenous drip (250 micrograms/h), started at the beginning of operation, while the latter (C) made up the control group. Serum and urine amylase, amylase creatinine clearance ratio, and liver function tests were assessed for 2 days before surgery, after the operation and for a period of 5 postoperative days. Homogeneity between the two series was verified in experimental conditions. Statistical differences occurred postoperatively in amylase creatinine clearance ratio, which proved higher in C group, and gamma-GT, which was higher in T group. Short-term somatostatin administration proved effective in reducing the postoperative amylase creatinine clearance ratio, although more evident results are reported after long-term administration. Cholestasis or any serious impairment in liver function did not occur, suggesting the suitability of somatostatin use even in patients with jaundice. Since a relationship between postoperative amylase levels and risk of pancreatitis has not yet been proved, the value of somatostatin in the prevention of postoperative pancreatitis after sphincteroplasty needs to be further verified.
20例行胆石症括约肌成形术的患者被随机分为两组，每组10人。前一组（T组）在手术开始时接受4小时的生长抑素静脉滴注（250微克/小时），后一组（C组）作为对照组。在手术前2天、手术后及术后5天期间评估血清和尿淀粉酶、淀粉酶肌酐清除率及肝功能测试。在实验条件下验证了两组之间的同质性。术后淀粉酶肌酐清除率出现统计学差异，C组较高，γ-谷氨酰转移酶（γ-GT）也出现差异，T组较高。短期给予生长抑素被证明可有效降低术后淀粉酶肌酐清除率，尽管长期给药后效果更明显。未发生胆汁淤积或任何严重肝功能损害，表明生长抑素即使在黄疸患者中使用也是合适的。由于术后淀粉酶水平与胰腺炎风险之间的关系尚未得到证实，生长抑素在预防括约肌成形术后胰腺炎方面的价值需要进一步验证。
